The number and diversity of surface plasmon resonance (SPR) biosensor applications
continue to increase. Evolutions in instrument and sensor chip technology, experimental …

Examination of the literature for period of this review revealed nearly two hundred citations
that employed surface plasmon resonance (SPR) spectroscopy using BIAcore technology to …

Adeno-associated viruses (AAV) are ubiquitous in the human population (> 90% of adults
are seropositive) but have never been implicated as the cause of any disease. They were …

PEGylation is an attractive strategy to enhance the therapeutic efficacy of proteins with a
short serum half-life. It can be used to extend the serum persistence and to reduce the …

A method was developed to rapidly identify high-affinity human antibodies from phage
display library selection outputs. It combines high-throughput Fab fragment expression and …

Ongoing clinical trials are exploring anticancer approaches based on signaling by TRAIL, a
ligand for the cell death receptors DR4 and DR5. In this study, we report on the selective …

Methods for detecting estradiol and metabolites thereof in a sample are provided. A plurality
of particles, each of which is coated with a capture agent having an affinity forestradiol, is …

The introduction of affinity-based biosensors has permitted label-free functional analysis of
biomolecular interactions in real time. A variety of methods are now based on BIACORE® …

SPR biosensor technology continues to evolve. The recently released platform from Biacore
AB (Uppsala, Sweden), BIACORE J, is designed for the routine analysis of biomolecular …

Accurate determination of kinetic rate constants for interacting biomolecules requires
knowledge of the active concentrations of the participating molecules. Also, in other …