Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Autophagy is a cellular degradative pathway that plays diverse roles in maintaining cellular
homeostasis. Cellular stress caused by starvation, organelle damage, or proteotoxic …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by an
intense fibrotic stromal response and deregulated metabolism,,,. The role of the stroma in …

Pancreatic ductal adenocarcinoma is prone to distant metastasis and is expected to become
the second leading cause of cancer-related death. In an extremely nutrient-deficient and …

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell
viability due to increased free radicals and reduced energy production. In pancreatic cancer …

Cancer is an evolutionary disease, containing the hallmarks of an asexually reproducing
unicellular organism subject to evolutionary paradigms. Pancreatic ductal adenocarcinoma …

Pancreatic cancer is a disease with limited therapeutic options. Resistance to
chemotherapies poses a significant clinical challenge for patients with pancreatic cancer …

Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are
in need of novel therapies. We have shown previously that these tumours have altered …

Pancreatic ductal adenocarcinoma (PDAC) is considered to be a highly immunosuppressive
and heterogenous neoplasm. Despite improved knowledge regarding the genetic …

With 5-year survival rates remaining constant at 6% and rising incidences associated with
an epidemic in obesity and metabolic syndrome, pancreatic ductal adenocarcinoma (PDAC) …