[HTML][HTML] The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
KE De Visser, JA Joyce - Cancer cell, 2023 - cell.com
Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …
Macrophages as tools and targets in cancer therapy
A Mantovani, P Allavena, F Marchesi… - Nature Reviews Drug …, 2022 - nature.com
Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …
Clinical relevance of tumour-associated macrophages
MJ Pittet, O Michielin, D Migliorini - Nature reviews Clinical oncology, 2022 - nature.com
In the past decade, substantial advances have been made in understanding the biology of
tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …
tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …
Toll-like receptor signaling and its role in cell-mediated immunity
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
Myeloid cell-targeted therapies for solid tumours
Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …
where they have a variety of functions, ranging from immunosuppressive to …
Tumor‐associated macrophages in liver cancer: from mechanisms to therapy
K Cheng, N Cai, J Zhu, X Yang, H Liang… - Cancer …, 2022 - Wiley Online Library
Multidimensional analyses have demonstrated the presence of a unique tumor
microenvironment (TME) in liver cancer. Tumor‐associated macrophages (TAMs) are …
microenvironment (TME) in liver cancer. Tumor‐associated macrophages (TAMs) are …
Immunosenescence, aging and successful aging
Y Wang, C Dong, Y Han, Z Gu, C Sun - Frontiers in immunology, 2022 - frontiersin.org
Aging induces a series of immune related changes, which is called immunosenescence,
playing important roles in many age-related diseases, especially neurodegenerative …
playing important roles in many age-related diseases, especially neurodegenerative …
Biosynthesized gold nanoparticles that activate Toll-like receptors and elicit localized light-converting hyperthermia for pleiotropic tumor immunoregulation
H Qin, Y Chen, Z Wang, N Li, Q Sun, Y Lin… - Nature …, 2023 - nature.com
Manipulating the tumor immune contexture towards a more active state can result in better
therapeutic outcomes. Here we describe an easily accessible bacterial biomineralization …
therapeutic outcomes. Here we describe an easily accessible bacterial biomineralization …
Exploiting innate immunity for cancer immunotherapy
M Yi, T Li, M Niu, Q Mei, B Zhao, Q Chu, Z Dai, K Wu - Molecular cancer, 2023 - Springer
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …
However, most of these immunomodulatory strategies focus on harnessing adaptive …
Innate immunity and cancer pathophysiology
Chronic inflammation increases the risk of several cancers, including gastric, colon, and
hepatic cancers. Conversely, tumors, similar to tissue injury, trigger an inflammatory …
hepatic cancers. Conversely, tumors, similar to tissue injury, trigger an inflammatory …