Abstract Knowledge of the immunological events necessary to control hepatitis B virus
(HBV) infection has accelerated in recent years, but their translation towards therapeutic …

Patients with chronic hepatitis B (CHB) can be successfully treated using nucleos (t) ide
analogs (NA), but drug-resistant hepatitis B virus (HBV) mutants frequently arise, leading to …

HBV infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Although
HBV infection can be efficiently prevented by vaccination, and treatments are available, to …

Hepatitis B virus (HBV) chronically infects 400 million people worldwide and is a leading
driver of end-stage liver disease and liver cancer. Research into the biology and treatment of …

Hepatitis B virus (HBV) infection acquired in adult life is generally self‐limited while chronic
persistence of the virus is the prevalent outcome when infection is acquired perinatally. Both …

The long-lasting persistence of HBV genomes in the liver (and in some cases also in the
serum) of HBsAg negative subjects is termed occult HBV infection (OBI). This peculiar …

Background & Aims Most viruses are detected at early stages of cell infection and induce an
innate immune response mediated by production of interferons (IFNs). IFNs induce …

Chronic hepatitis B virus (HBV) infection remains a major health burden and the main risk
factor for the development of hepatocellular carcinoma worldwide. However, HBV is not …

In this review we give a brief update on sensors recently determined to be capable of
detecting HBV, and examine how the virus represses the induction of pro-inflammatory …

The cellular innate immune system recognizing pathogen infection is essential for host
defense against viruses. In parallel, viruses have developed a variety of strategies to evade …