Triple-negative breast cancer (TNBC) is the most aggressive subtype of mammary
carcinoma. Here, we describe a case of an 81-year-old female diagnosed with ductal triple …

Time-of-day significantly influences the severity and incidence of stroke. Evidence has
emerged not only for circadian governance over stroke risk factors, but also for important …

Genomic instability, a hallmark of cancer, is a direct consequence of the inactivation of the
tumor suppressor protein p53. Genetically modified mouse models and human tumor …

We investigated the presence of aluminium (Al) in human colon cancer samples and its
potential association with biological processes involved in cancer progression, such as …

BAX and BAK are proapoptotic members of the BCL2 family that directly mediate
mitochondrial outer membrane permeabilition (MOMP), a central step in apoptosis …

Simple Summary Inflammation and free radicals can stimulate cell self-destruction.
Inflammation and cell death are vital aspects of most diseases. Accumulation of cell damage …

Cell death can be classified into two primary categories: accidental cell death and regulated
cell death (RCD). Within RCD, there are distinct apoptotic and non-apoptotic cell death …

SUMMARY TP53-mutant blood cancers remain a clinical challenge. BH3-mimetic drugs
inhibit BCL-2 pro-survival proteins, inducing cancer cell apoptosis. Despite acting …

Programmed cell death (self-induced) is intrinsic to all cellular life forms, including
unicellular organisms. However, cell death research has focused on animal models to …

OTX homeobox genes have been extensively studied for their role in development,
especially in neuroectoderm formation. Recently, their expression has also been reported in …