Gasdermins (GSDMs) serve as pivotal executors of pyroptosis and play crucial roles in host
defence, cytokine secretion, innate immunity, and cancer. However, excessive or …

Background Acute cholangitis is a severe, life-threatening infection of the biliary system that
requires early diagnosis and treatment. The Tokyo Guidelines recommend a combination of …

Host control over infectious disease relies on the ability of cells in multicellular organisms to
detect and defend against pathogens to prevent disease. Evolution affords mammals with a …

Patulin (PAT) is the most common mycotoxin found in moldy fruits and their derived
products, and is reported to cause diverse toxic effects, including hepatotoxicity …

Paclitaxel serves as the cornerstone chemotherapy for ovarian cancer, yet its prolonged
administration frequently culminates in drug resistance, presenting a substantial challenge …

The uc. 291 transcript controls keratinocytes differentiation by physical interaction with
ACTL6A and subsequent induction of transcription of the genes belonging to the epidermal …

Billions of cells die in us every hour, and our tissues do not shrink because there is a natural
regulation where Cell Death (CD) is balanced with cell division. The process in which cells …

Tumour immune microenvironment (TIME) plays an indispensable role in tumour
progression, and tumour‐associated macrophages (TAMs) are the most abundant immune …

Intracerebral hemorrhage (ICH) is a life-threatening condition associated with significant
morbidity and mortality. This study investigates transcriptomic alterations in rodent models of …

Urolithiasis is a high‑incidence disease caused by calcium oxalate (mainly), uric acid,
calcium phosphate, struvite, apatite, cystine and other stones. The development of kidney …