[HTML][HTML] Genomic and transcriptomic profiling of hepatocellular carcinoma reveals a rare molecular subtype
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death
worldwide, occurring predominantly in patients with underlying chronic liver disease and …
worldwide, occurring predominantly in patients with underlying chronic liver disease and …
[HTML][HTML] A New Paradigm in Intracellular Immunology: Mitochondria Emerging as Leading Immune Organelles
Mitochondria, traditionally recognized as cellular'powerhouses' due to their pivotal role in
energy production, have emerged as multifunctional organelles at the intersection of …
energy production, have emerged as multifunctional organelles at the intersection of …
[HTML][HTML] The Role of FKBPs in Complex Disorders: Neuropsychiatric Diseases, Cancer, and Type 2 Diabetes Mellitus
G Agam, B Atawna, O Damri, AN Azab - Cells, 2024 - mdpi.com
Stress is a common denominator of complex disorders and the FK-506 binding protein
(FKBP) 51 plays a central role in stress. Hence, it is not surprising that multiple studies imply …
(FKBP) 51 plays a central role in stress. Hence, it is not surprising that multiple studies imply …
[HTML][HTML] 8-Br-cGMP activates HSPB6 and increases the antineoplastic activity of quinidine in prostate cancer
Y Feng, Z Huang, F Lu, L Song, R Liu, Y Zhang… - Cell Death …, 2024 - nature.com
Heat shock protein family B [small] member 6 (HSPB6), widely found in various muscles, has
been recently identified as a tumor suppressor gene. However, its role in prostate cancer …
been recently identified as a tumor suppressor gene. However, its role in prostate cancer …
[HTML][HTML] Classical apoptotic stimulus, staurosporine, induces lytic inflammatory cell death, PANoptosis
Innate immunity is the body's first line of defense against disease, and regulated cell death is
a central component of this response that balances pathogen clearance and inflammation …
a central component of this response that balances pathogen clearance and inflammation …
[HTML][HTML] When therapy-induced cancer cell apoptosis fuels tumor relapse
R Mirzayans - Onco, 2024 - mdpi.com
Simple Summary For nearly half a century, a mainstay and goal of medical oncology has
been to identify novel anticancer drugs and therapeutic strategies to promote the effective …
been to identify novel anticancer drugs and therapeutic strategies to promote the effective …
Hyaluronic acid metabolism and chemotherapy resistance: recent advances and therapeutic potential
Hyaluronic acid (HA) is a major component of the extracellular matrix, providing essential
mechanical scaffolding for cells and, at the same time, mediating essential biochemical …
mechanical scaffolding for cells and, at the same time, mediating essential biochemical …
[HTML][HTML] AI-driven transcriptomic encoders: From explainable models to accurate, sample-independent cancer diagnostics
D Croce, A Smirnov, L Tiburzi, S Travaglini… - Expert Systems with …, 2024 - Elsevier
In the rapidly evolving domain of medical technology, the utilization of sophisticated
algorithms for deciphering transcriptional data has emerged as a critical aspect, especially …
algorithms for deciphering transcriptional data has emerged as a critical aspect, especially …
Palladium (II) compounds containing oximes as promising antitumor agents for the treatment of osteosarcoma: An in vitro and in vivo comparative study with cisplatin
THR Pereira, TR de Moura, MRM Santos… - European Journal of …, 2024 - Elsevier
Drug resistance, evasion of cell death and metastasis are factors that contribute to the low
cure rate and disease-free survival in osteosarcomas (OS). In this study, we demonstrated …
cure rate and disease-free survival in osteosarcomas (OS). In this study, we demonstrated …
An early regulatory mechanism of hyperinflammation by restricting monocyte contribution
M Akiyama, M Kanayama, Y Umezawa… - Frontiers in …, 2024 - frontiersin.org
Innate immune cells play a key role in inflammation as a source of pro-inflammatory
cytokines. However, it remains unclear how innate immunity-mediated inflammation is fine …
cytokines. However, it remains unclear how innate immunity-mediated inflammation is fine …