Changing the Landscape of Solid Tumor Therapy from Apoptosis-Promoting to Apoptosis-Inhibiting Strategies

R Mirzayans - Current Issues in Molecular Biology, 2024 - mdpi.com
The many limitations of implementing anticancer strategies under the term “precision
oncology” have been extensively discussed. While some authors propose promising future …

Noncoding RNAs in Hepatitis: Unraveling the Apoptotic Pathways

KS Alharbi - Pathology-Research and Practice, 2024 - Elsevier
Hepatitis is a worldwide health issue that causes inflammation of the liver and is frequently
brought on by viral infections, specifically those caused by the hepatitis B and C viruses …

Proteomic study on nintedanib in gastric cancer cells

X Dong, L Wang, D Wang, M Yu, X jun Yang, H Cai - PeerJ, 2024 - peerj.com
Background Gastric cancer is a very common gastrointestinal tumor with a high mortality
rate. Nintedanib has been shown to significantly reduce tumor cell proliferation and increase …

Neurotoxic β-amyloid oligomers cause mitochondrial dysfunction—the trigger for PANoptosis in neurons

X Meng, Q Song, Z Liu, X Liu, Y Wang… - Frontiers in Aging …, 2024 - frontiersin.org
As the global population ages, the incidence of elderly patients with dementia, represented
by Alzheimer's disease (AD), will continue to increase. Previous studies have suggested that …

Leveraging the redundancy of S-denitrosylases in response to S-nitrosylation of Caspases: experimental strategies and beyond

S Chakraborty, A Mishra, A Choudhuri, T Bhaumik… - Nitric Oxide, 2024 - Elsevier
Redox-based protein posttranslational modifications, such as S-nitrosylation of critical,
active site cysteine thiols have garnered significant clinical attention and research interest …

Role of Exosomes in Cancer and Aptamer-Modified Exosomes as a Promising Platform for Cancer Targeted Therapy

Y Wu, Y Cao, L Chen, X Lai, S Zhang… - Biological Procedures …, 2024 - Springer
Exosomes are increasingly recognized as important mediators of intercellular
communication in cancer biology. Exosomes can be derived from cancer cells as well as …

[HTML][HTML] Exploring the Dark Matter of Human Proteome: The Emerging Role of Non-Canonical Open Reading Frame (ncORF) in Cancer Diagnosis, Biology, and …

A Ge, C Chan, X Yang - Cancers, 2024 - mdpi.com
Simple Summary With advanced bioinformatic and sequencing technologies, many non-
coding RNAs have been found to harbor non-canonical open reading frames (ncORFs) …

Discovery of novel 5-phenylpyrazol receptor interacting protein 1 (RIP1) kinase inhibitors as anti-necroptosis agents by combining virtual screening and in vitro and in …

Y Shi, J Tang, S Zhi, R Jiang, Q Huang, L Sun… - Bioorganic …, 2024 - Elsevier
Necroptosis is one of the modes of cell death, and its occurrence and development are
associated with the development of numerous diseases. To prevent the progression of …

Machine Learning Screening and Validation of PANoptosis-Related Gene Signatures in Sepsis

J Xu, M Zhu, P Luo, Y Gong - Journal of Inflammation Research, 2024 - Taylor & Francis
Background Sepsis is a syndrome marked by life-threatening organ dysfunction and a
disrupted host immune response to infection. PANoptosis is a recent conceptual …

Cell Death in Liver Disease and Liver Surgery

C Stoess, YK Choi, J Onyuru, H Friess, HM Hoffman… - Biomedicines, 2024 - mdpi.com
Cell death is crucial for maintaining tissue balance and responding to diseases. However,
under pathological conditions, the surge in dying cells results in an overwhelming presence …