Genetically driven predisposition leads to an unusually genomic unstable renal cell carcinoma
Renal cell carcinoma originates from the lining of the proximal convoluted renal tubule and
represents the most common type of kidney cancer. Risk factors and comorbidities might be …
represents the most common type of kidney cancer. Risk factors and comorbidities might be …
A Machine Learning Computational Framework Develops a Multiple Programmed Cell Death Index for Improving Clinical Outcomes in Bladder Cancer
C Li, W Qin, J Hu, J Lin, Y Mao - Biochemical Genetics, 2024 - Springer
Comprehensive action patterns of programmed cell death (PCD) in bladder cancer (BLCA)
have not yet been thoroughly investigated. Here, we collected 19 different PCD patterns …
have not yet been thoroughly investigated. Here, we collected 19 different PCD patterns …
When Therapy-Induced Cancer Cell Apoptosis Fuels Tumor Relapse
R Mirzayans - Onco, 2024 - mdpi.com
Simple Summary For nearly half a century, a mainstay and goal of medical oncology has
been to identify novel anticancer drugs and therapeutic strategies to promote the effective …
been to identify novel anticancer drugs and therapeutic strategies to promote the effective …
A novel lncRNA associated with the prognosis of patients with colorectal cancer resists apoptosis through the LYN/BCL-2 pathway
G An, J Hui, W Zhang, A Fan, Y Zhou, X Zhao… - Biochemical and …, 2024 - Elsevier
Purpose We found a novel lncRNA named lncAC138150. 2 related to the overall survival
and staging of patients with colorectal cancer (CRC) by bioinformatic analysis using data …
and staging of patients with colorectal cancer (CRC) by bioinformatic analysis using data …
Programmed Cell Death and its Implications for Skeletal Muscle Wasting
R Dabur, A Yadav - Indian Journal of Clinical Biochemistry, 2024 - Springer
Skeletal muscle atrophy is an inevitable sequel of various factors such as cachexia, aging,
fasting, denervation, and microgravity. It is characterized by reduced muscle protein through …
fasting, denervation, and microgravity. It is characterized by reduced muscle protein through …
Structural modification of naturally occurring phenolics as a strategy for developing cytotoxic molecules towards cancer cells
P Olim, RB Pereira, MJG Fernandes… - Archiv der …, 2023 - Wiley Online Library
Natural products belonging to different chemical classes have been established as a
promising source of novel anticancer drugs. Several low‐molecular‐weight compounds from …
promising source of novel anticancer drugs. Several low‐molecular‐weight compounds from …
[HTML][HTML] Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer
X Jin, W Jin, L Tong, N Lin, L Zhang, J Zhao - Acta Pharmaceutica Sinica B, 2024 - Elsevier
Regulated cell death (RCD) is a controlled form of cell death orchestrated by one or more
cascading signaling pathways, making it amenable to pharmacological intervention. RCD …
cascading signaling pathways, making it amenable to pharmacological intervention. RCD …
The Hemerocallis citrina extracts ameliorate radiation-induced ferroptosis in LO2 cells through the Nrf2-xCT/GPX4 pathway
Z Zhu, Y Wang, Z Deng, P Lei, Q Liu… - … and Herbal Medicine, 2024 - journals.lww.com
Background: Radiotherapy, a primary approach in cancer treatment, damages normal cells
while targeting cancer cells. Therefore, it is crucial to identify drugs with minimal side effects …
while targeting cancer cells. Therefore, it is crucial to identify drugs with minimal side effects …
[HTML][HTML] Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges
Z Zhang, L Hou, D Liu, S Luan, M Huang… - … Pharmaceutica Sinica B, 2024 - Elsevier
For over two decades, the development of B-cell lymphoma-2 (Bcl-2) family therapeutics has
primarily focused on anti-apoptotic proteins, resulting in the first-in-class drugs called BH3 …
primarily focused on anti-apoptotic proteins, resulting in the first-in-class drugs called BH3 …
Evaluation of Cytotoxicity, Cell-Cycle Arrest, and Apoptotic Induction of Three Ruellia tuberosa Leaf Extracts in MCF-7 Cells
This study investigated the mechanisms responsible for the antiproliferative activities of
three Ruellia tuberosa (RT) leaf extracts against MCF-7 cells after liquid-liquid partitioning …
three Ruellia tuberosa (RT) leaf extracts against MCF-7 cells after liquid-liquid partitioning …