A dramatic maturational process ongoing in adolescence is prefrontal cortex development,
including its dopamine innervation. Dopamine axons grow from the striatum to the prefrontal …

Cognitive dysfunction is a core feature of schizophrenia. Growing evidence indicates that a
wide variety of genetic mutations and polymorphisms impact cognition and may thus be …

Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene, first described in 2004 have
now emerged as the most important genetic finding in both autosomal dominant and …

The current dopamine (DA) hypothesis of schizophrenia postulates striatal
hyperdopaminergia and cortical hypodopaminergia. Although partial agonists at DA D2 …

Social stress in adolescence is correlated with emergence of psychopathologies during
early adulthood. In this study, the authors investigated the impact of social defeat stress …

Disruption of the dopamine (DA) transporter (Dat1) gene in mice leads to a 50% reduction or
complete elimination of Dat1 expression in striatum of respective heterozygous (HZ) and …

Netrins are guidance cues involved in neural connectivity. We have shown that the netrin-1
receptor DCC (deleted in colorectal cancer) is involved in the functional organization of the …

Increasing evidence suggests that in addition to the mesoaccumbens dopamine (DA)
system other neurotransmitter and brain systems are also involved in opiate addiction …

Multiple lines of evidence demonstrate that the noradrenergic system provides both direct
and indirect excitatory drive onto midbrain dopamine (DA) neurons. We used DA β …

Rationale In previous studies, we have demonstrated that mice of the inbred strain
C57BL/6J (C57) are more susceptible to amphetamine-induced conditioned place …