Cholinergic neurotransmission exerts widespread modulation of brain function. The focus of
my thesis is to detail the neurophysiological and behavioural function of acetylcholine in the …

La dipendenza da sostanze è un tipico esempio di interazione tra fattori genetici e
ambientali nel quale l'influenza dei fattori genetici è largamente prevalente. Studi di …

Victims of teenage bullying show increased drug abuse as adults; however, the underlying
neural mechanisms are not well understood. Our prior work suggests a role for stress …

McDonald et al. 2006, Velakoulis et al. 2006, Goldman et al. 2007, Metaanalyse von Helen
et al. 2007). Auch eine verkleinerte Teilstruktur des Hippokampus ist bei schizophrenen …

Drug addiction is a chronic compulsion and relapsing disorder defined as a “pathological
pattern of use of a substance”, and characterized by the loss of control in drug-taking-related …

Abstract The netrin-1 receptor, DCC, determines a) the extent of dopamine innervation to the
medial prefrontal cortex, b) the organization of local circuitry, and c) individual vulnerability …

6.1 Objective The overall objective of this thesis was to gain insight in the genes and
pathways involved in psychosis susceptibility. For this purpose we first generated …

Psychostimulants are addictive drugs that exert their effects mainly through inhibition of the
dopamine, norepinephrine, and serotonin transporter reuptake activities. Previous studies …

Schizophrenia, a severe psychiatric disorder with symptoms that emerge predominately in
young adulthood, is thought to result from disruptions in the normal course of …

Disruption to the development of the mesocorticolimbic dopamine (DA) system is thought to
contribute to the symptomatology of schizophrenia and related disorders. However, the …