Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Cancer cells undergo metabolic reprogramming and switch to a 'glycolysis-
dominant'metabolic profile to promote their survival and meet their requirements for energy …

Acidic environments reduce the intracellular pH (pHi) of most cells to levels that are sub-
optimal for growth and cellular functions. Yet, cancers maintain an alkaline cytoplasm …

Cancer cells and immune cells all undergo remarkably metabolic reprogramming during the
oncogenesis and tumor immunogenic killing processes. The increased dependency on …

Ions are the cornerstones of various biological functions and have been widely used for
tumor therapy, called ion interference therapy (IIT). Calcium ion (Ca 2+) is one of the most …

Background Exosomes are a new class of molecular entities in the metastatic
microenvironment, which can mediate bidirectional communication between cells. While …

Background and aim: As non-coding RNAs, circular RNAs (circRNAs) contribute to the
progression of malignancies by regulating various biological processes. In prostate cancer …

Introduction In view of other candidate proteins from the cathepsin family of proteases
holding great potential in being targeted during cancer therapy, the importance of Cathepsin …

Hyperforin (HPF), the main component responsible for the antidepressant action of
Hypericum perforatum, displays additional beneficial properties including anti-inflammatory …

Glutathione peroxidase 4 (GPX4) has been reported as one of the major targets for
ferroptosis induction, due to its pivotal role in lipid hydroperoxide removal. However, recent …