The role of TH17 cells in multiple sclerosis: Therapeutic implications
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …
[HTML][HTML] The immunology of Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder which
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …
Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid
C Schläger, H Körner, M Krueger, S Vidoli, M Haberl… - Nature, 2016 - nature.com
In multiple sclerosis, brain-reactive T cells invade the central nervous system (CNS) and
induce a self-destructive inflammatory process. T-cell infiltrates are not only found within the …
induce a self-destructive inflammatory process. T-cell infiltrates are not only found within the …
CXCR3 in T cell function
JR Groom, AD Luster - Experimental cell research, 2011 - Elsevier
CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …
CXCR3 ligands: redundant, collaborative and antagonistic functions
JR Groom, AD Luster - Immunology and cell biology, 2011 - Wiley Online Library
CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation,
and preferentially remains highly expressed on type‐1 helper (Th1)‐type CD4+ T cells …
and preferentially remains highly expressed on type‐1 helper (Th1)‐type CD4+ T cells …
Proinflammatory CD20+ T cells contribute to CNS-directed autoimmunity
J Ochs, N Nissimov, S Torke, M Freier… - Science translational …, 2022 - science.org
The origin and function of CD20+ T cells are poorly understood. Here, we characterized
CD20+ T cells in mice and humans and investigated how they are affected by anti-CD20 …
CD20+ T cells in mice and humans and investigated how they are affected by anti-CD20 …
T cells become licensed in the lung to enter the central nervous system
F Odoardi, C Sie, K Streyl, VK Ulaganathan… - Nature, 2012 - nature.com
The blood–brain barrier (BBB) and the environment of the central nervous system (CNS)
guard the nervous tissue from peripheral immune cells. In the autoimmune disease multiple …
guard the nervous tissue from peripheral immune cells. In the autoimmune disease multiple …
[HTML][HTML] Trigger-happy resident memory CD4+ T cells inhabit the human lungs
AE Oja, B Piet, C Helbig, R Stark, D Van Der Zwan… - Mucosal …, 2018 - Elsevier
Resident memory T cells (T RM) reside in the lung epithelium and mediate protective
immunity against respiratory pathogens. Although lung CD8+ T RM have been extensively …
immunity against respiratory pathogens. Although lung CD8+ T RM have been extensively …
[HTML][HTML] STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation
Abstract T helper (TH)-cell subsets, such as TH 1 and TH 17, mediate inflammation in both
peripheral tissues and central nervous system. Here we show that STAT5 is required for T …
peripheral tissues and central nervous system. Here we show that STAT5 is required for T …
Age-associated resident memory CD8 T cells in the central nervous system are primed to potentiate inflammation after ischemic brain injury
Aging is associated with an increase in basal inflammation in the CNS and an overall
decline in cognitive function and poorer recovery following injury. Growing evidence …
decline in cognitive function and poorer recovery following injury. Growing evidence …