Rho-associated coiled-coil kinase (ROCK), a serine/threonine kinase regulated by the small
GTPase RhoA, is involved in regulating cell migration, proliferation, and survival. Numerous …

Fungal infections of the central nervous system (FI-CNS) are a problematic and important
medical challenge considering that those most affected are immunocompromised …

Rho family GTPases serve as molecular switches in numerous cellular processes, and their
overexpression is involved in disease conditions. RhoG is one of the less explored Rho …

The vertebrate intestinal system consists of separate segments that remarkably differ in
morphology and function. However, the origin of intestinal segmentation remains unclear. In …

Hypertensive cerebral microbleeds (HCMB) may be the early stage of hypertensive
intracerebral hemorrhage (HICH), which is a serious threat to health due to its high mortality …

Background Human restricted genes contribute to human specific traits in the immune
system. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of the α7 …

Background RhoG is a multifaceted member of the Rho family of small GTPases, sharing the
highest sequence identity with the Rac subfamily members. It acts as a molecular switch …

Persistent breeding induced endometritis (PBIE) is a significant cause of infertility in mares.
The development of a safe, universal, readily available therapeutic to manage PBIE and …

Post-sepsis early mortality is being replaced by survivors who experience either a rapid
recovery and favorable hospital discharge or the development of chronic critical illness (CCI) …

Objective To investigate the role and mechanism of Rho-related GTP-binding protein F
(RhoF)-mediated Th17 polarization in the development of severe acute pancreatitis (SAP) …