Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

The structural diversity and functional relevance of nucleic acids (NAs), mainly
deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are indispensable for almost all …

The quest for small molecules that strongly bind to G-quadruplex-DNA (G4), so-called G4
ligands, has invigorated the G4 research field from its very inception. Massive efforts have …

Objectives A dynamic G-quadruplex region has been previously shown to form in the long
terminal repeat (LTR) promoter of the HIV-1 integrated DNA genome. Inhibition of promoter …

Designing ligands targeting G-quadruplex nucleic acid structures and affecting cellular
processes is complicated because there are multiple target sequences and some are …

Four-stranded G-quadruplex (G4) DNA structures are promising drug targets as these non-
canonical structures appear to regulate gene expression and telomere growth. Although all …

The rational design of ligands targeting human telomeric DNA G-quadruplexes is a complex
problem due to the structural polymorphism that these sequences can adopt in physiological …

The potential formation of G-quadruplexes in many regions of the genome makes them an
attractive target for drug design. A large number of small molecules synthesized in recent …

Guanine-rich sequences can fold into four-stranded structures of stacked guanine-tetrads,
so-called G-quadruplexes (G4). These unique motifs have been extensively studied on the …

The ability of the guanine-rich strand of the human mitochondrial DNA (mtDNA) to form G-
quadruplex structures (G4s) has been recently highlighted, suggesting potential functions in …