Therapeutic potential of allicin and aged garlic extract in Alzheimer's disease

P Tedeschi, M Nigro, A Travagli, M Catani… - International Journal of …, 2022 - mdpi.com
Garlic, Allium sativum, has long been utilized for a number of medicinal purposes around the
world, and its medical benefits have been well documented. The health benefits of garlic …

Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer's disease

J Chang, Y Li, X Shan, X Chen, X Yan… - Neural Regeneration …, 2024 - journals.lww.com
Recent studies have demonstrated that neuroplasticity, such as synaptic plasticity and
neurogenesis, exists throughout the normal lifespan but declines with age and is …

Metformin a potential pharmacological strategy in late onset Alzheimer's disease treatment

SR Poor, M Ettcheto, A Cano, E Sanchez-Lopez… - Pharmaceuticals, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the most devastating brain disorders. Currently, there are
no effective treatments to stop the disease progression and it is becoming a major public …

[HTML][HTML] Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an …

S Gonzalez, TLM McHugh, T Yang, W Syriani… - Neurobiology of …, 2022 - Elsevier
Degeneration of basal forebrain cholinergic neurons (BFCNs) in the nucleus basalis of
Meynert (NBM) and vertical diagonal band (VDB) along with their connections is a key …

New strategies for the treatment of neuropsychiatric disorders based on reelin dysfunction

Y Tsuneura, T Nakai, H Mizoguchi… - International journal of …, 2022 - mdpi.com
Reelin is an extracellular matrix protein that is mainly produced in Cajal-Retzius cells and
controls neuronal migration, which is important for the proper formation of cortical layers in …

Insight into the emerging and common experimental in-vivo models of Alzheimer's disease

R Dhapola, S Kumari, P Sharma… - Laboratory Animal …, 2023 - Springer
Alzheimer's disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder.
As the exact cause of the disease is still unclear, the drug development is very challenging …

[HTML][HTML] Targeting autophagy in Alzheimer's disease: Animal models and mechanisms

XW Zhang, XX Zhu, DS Tang, JH Lu - Zoological research, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder that
leads to cognitive impairment and memory loss. Emerging evidence suggests that …

Impact of Caffeine on Alzheimer's Disease Pathogenesis—Protective or Risk Factor?

TG Schreiner, BO Popescu - Life, 2022 - mdpi.com
Alzheimer's disease (AD), the most common dementia worldwide, remains without an
effective treatment to this day despite intensive research conducted during the last decades …

Altered mitochondrial morphology and bioenergetics in a new yeast model expressing Aβ42

KK Epremyan, AG Rogov, TN Goleva… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is an incurable, age-related neurological disorder, the most
common form of dementia. Considering that AD is a multifactorial complex disease …

Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer's Disease

NM Tataryn, V Singh, JP Dyke, HE Berk-Rauch… - Neurobiology of …, 2021 - Elsevier
Vascular perturbations and cerebral hypometabolism are emerging as important
components of Alzheimer's disease (AD). While various in vivo imaging modalities have …