Inflammation is one of the most characteristic features of chronic liver disease of viral,
alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease …

Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Hepatic myofibroblasts are activated in response to chronic liver injury of any etiology to
produce a fibrous scar. Despite extensive studies, the origin of myofibroblasts in different …

Primary sclerosing cholangitis is the classic hepatobiliary manifestation of inflammatory
bowel disease and is generally chronic and progressive. Patients frequently present with …

Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by
autoimmune destruction of small to medium size intrahepatic bile ducts. The etiology of PBC …

Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …

Mass spectrometry (MS)-based proteomics provides a powerful approach to globally
investigate the biological function of individual cell types in mammalian organs. Here, we …

Biliary atresia (BA) is a devastating fibro-inflammatory disease characterized by the
obstruction of extrahepatic and intrahepatic bile ducts in infants that can have fatal …

Cholangiocytes, the epithelial cells lining the bile ducts, are an important subset of liver
cells. They are involved in the modification of bile volume and composition, and respond to …