Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …

Glycosaminoglycans (GAGs) as one major part of the glycocalyx are involved in many
essential biological cell processes, as well as in many courses of diseases. Because of the …

Hyaluronan synthases (HASs) are glycosyltransferases that catalyze polymerization of
hyaluronan found in vertebrates and certain microbes. HASs transfer two distinct …

Hyaluronan (HA) biosynthesis has been studied for over six decades, but our understanding
of the biochemical details of how HA synthase (HAS) assembles HA is still incomplete. Class …

Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular
hyaluronan synthesis. Interest in HAS1 has been limited because its role in hyaluronan …

Given the constant synthesis and degradation of hyaluronan (hyaluronic acid, HA) in tissues,
it is remarkable that the human body maintains precise levels of hyaluronan as tightly as it …

The wall of an expanding plant cell consists primarily of cellulose microfibrils embedded in a
matrix of hemicellulosic and pectic polysaccharides along with small amounts of structural …

Hyaluronan must be exported from its site of synthesis, the inner side of plasma membrane,
to the extracellular matrix. Here, we identified the multidrug-associated protein MRP5 as the …

The unique biological and rheological properties make hyaluronic acid a sought-after
material for medicine and cosmetology. Due to very high purity requirements for hyaluronic …

Glycosyltransferases (GT) catalyse the biosynthesis of complex carbohydrates which are the
most abundant group of molecules in nature. They are involved in several key mechanisms …