Some recent clinical and preclinical evidence suggests that neuroinflammation is a key
factor that interacts with the three neurobiological correlates of major depressive disorder …

A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Depression is a common and serious disorder, characterized by symptoms like anhedonia,
lack of energy, sad mood, low appetite, and sleep disturbances. This disease is very …

The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …

Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

The concept of the gut microbiome is emerging as a metabolic interactome influenced by
diet, xenobiotics, genetics, and other environmental factors that affect the host's absorption …

Globally, depression is a leading cause of disability and has remained so for decades.
Antidepressant medications have suboptimal outcomes and are too frequently associated …

This review summarizes the current knowledge on essential vitamins B1, B2, B3, and B5.
These B-complex vitamins must be taken from diet, with the exception of vitamin B3, that can …

NAD+ is a fundamental molecule in human life and health as it participates in energy
metabolism, cell signalling, mitochondrial homeostasis, and in dictating cell survival or …