The role of phosphate in kidney disease

MG Vervloet, S Sezer, ZA Massy, L Johansson… - Nature Reviews …, 2017 - nature.com
The importance of phosphate homeostasis in chronic kidney disease (CKD) has been
recognized for decades, but novel insights—which are frequently relevant to everyday …

Is chronic kidney disease-mineral bone disorder (CKD-MBD) really a syndrome?

M Cozzolino, P Ureña-Torres… - Nephrology Dialysis …, 2014 - academic.oup.com
The concept of chronic kidney disease–mineral bone disorder (CKD-MBD) does not appear
to fulfil the requirements for a syndrome at first glance, but its definition has brought some …

Gastrointestinal inhibition of sodium-hydrogen exchanger 3 reduces phosphorus absorption and protects against vascular calcification in CKD

ED Labonté, CW Carreras, MR Leadbetter… - Journal of the …, 2015 - journals.lww.com
In CKD, phosphate retention arising from diminished GFR is a key early step in a pathologic
cascade leading to hyperthyroidism, metabolic bone disease, vascular calcification, and …

Treatment of secondary hyperparathyroidism: the clinical utility of etelcalcetide

M Cozzolino, A Galassi, F Conte… - … and clinical risk …, 2017 - Taylor & Francis
Secondary hyperparathyroidism (SHPT), a very frequent, severe, and worsening
complication of chronic kidney disease, is characterized by high serum parathyroid hormone …

Balancing nutrition and serum phosphorus in maintenance dialysis

D Fouque, R Horne, M Cozzolino… - American journal of …, 2014 - Elsevier
Elevated serum phosphorus levels are common in patients with chronic kidney disease and
are associated with heart and vascular disease, conditions that in turn are associated with …

[HTML][HTML] Therapeutic effect of iron citrate in blocking calcium deposition in high Pi-calcified VSMC: role of autophagy and apoptosis

P Ciceri, M Falleni, D Tosi, C Martinelli… - International Journal of …, 2019 - mdpi.com
In chronic kidney disease (CKD), the first cause of mortality is cardiovascular disease
induced mainly by vascular calcification (VC). Recently, iron-based phosphate binders have …

Combined effects of ascorbic acid and phosphate on rat VSMC osteoblastic differentiation

P Ciceri, E Volpi, I Brenna, L Arnaboldi… - Nephrology Dialysis …, 2012 - academic.oup.com
Background. Ascorbic acid (AA) supplementation has been suggested to afford
erythropoietin hyporesponsiveness and high levels of ferritin in haemodialysis (HD) patients …

Management of secondary hyperparathyroidism in chronic kidney disease: a focus on the elderly

A Galassi, P Ciceri, E Fasulo, S Carugo, G Cianciolo… - Drugs & Aging, 2019 - Springer
Secondary hyperparathyroidism (SHPT) is a major complication of chronic kidney disease
(CKD), responsible for skeletal and vascular damage with increased risk of bone fractures …

Nutritional therapy, phosphate control and renal protection

JJ Carrero, M Cozzolino - Nephron Clinical Practice, 2014 - karger.com
Dietary management of chronic kidney disease (CKD) focusses on limiting the intake of
substances that might accumulate to toxic levels (such as potassium, phosphorus or salt) …

Emerging drugs for secondary hyperparathyroidism

M Cozzolino, J Tomlinson, L Walsh… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Secondary hyperparathyroidism (SHPT), a common, serious, and progressive
complication of chronic kidney disease (CKD), is characterized by elevated serum …