There has been much interest in the ability of regulatory T cells (Treg) to switch function in
vivo, either as a result of genetic risk of disease or in response to environmental and …

Abstract Recombinant interleukin-33 (IL-33) inhibits tumor growth, but the detailed
immunological mechanism is still unknown. IL-33-mediated tumor suppression did not occur …

Interleukin (IL)-33 is a member of the IL-1 superfamily and is a crucial cytokine playing the
role of a dual-function molecule. IL-33 mediates its function by interacting with its receptor …

ABSTRACT Introduction Regulatory T cells (Tregs) play a critical role in the maintenance of
immune homeostasis but also protect tumors from immune-mediated growth control or …

Oncolytic virotherapies are perceived as remarkable immunotherapies coming into view and
represent highly promising cancer treatments, yet to figure out its specific immune responses …

CD4+ T cell differentiation is governed by gene regulatory and metabolic networks, with both
networks being highly interconnected and able to adapt to external stimuli. Th17 and Tregs …

Simple Summary The tumor microenvironment (TME) plays an important role of cancer
recurrence and treatment resistance. The cytokines in the TME may involve the tumor …

Background RORγt+ Foxp3+ (Th17-like) Tregs are a plastic Treg subset implicated in
immune-related diseases; however, the mechanism of Treg phenotypic transformation in …

Abstract Purpose Forkhead Box Protein 3 (FoxP3) is known as a key mediator in the
immunosuppressive function of regulatory T-cells (Tregs). The aim of our study was to …

Interleukin-33 (IL-33) is a member of the IL-1 cytokine family and is believed to play
important roles in different diseases by binding to its specific receptor suppression of …