[PDF][PDF] Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside

MA Ghonim, DF Boyd, T Flerlage… - Journal of Clinical …, 2023 - Am Soc Clin Investig
In recent years, there has been an explosion of interest in how fibroblasts initiate, sustain,
and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets …

[HTML][HTML] HSP47: a therapeutic target in pulmonary fibrosis

N Sakamoto, D Okuno, T Tokito, H Yura, T Kido… - Biomedicines, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by a progressive
decline in lung function and poor prognosis. The deposition of the extracellular matrix (ECM) …

Nanoengineered mesenchymal stem cell therapy for pulmonary fibrosis in young and aged mice

MM Han, XY He, L Tang, L Qi, MY Yang, Y Wang… - Science …, 2023 - science.org
Pulmonary fibrosis (PF) is an age-related interstitial lung disease that results in notable
morbidity and mortality. The Food and Drug Administration–approved drugs can decelerate …

H3K18 lactylation promotes the progression of arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP

P Wang, D Xie, T Xiao, C Cheng, D Wang, J Sun… - Journal of Hazardous …, 2024 - Elsevier
As epigenetic modifications, lactylation and N6-methyladenosine (m6A) have attracted wide
attention. Arsenite is an environmental pollutant that has been proven to induce idiopathic …

Lipid metabolism in idiopathic pulmonary fibrosis: From pathogenesis to therapy

R Chen, J Dai - Journal of Molecular Medicine, 2023 - Springer
Idiopathic pulmonary fibrosis (IPF) is a chronic irreversible interstitial lung disease
characterized by a progressive decline in lung function. The etiology of IPF is unknown …

Chinese medicine as a therapeutic option for pulmonary fibrosis: clinical efficacies and underlying mechanisms

Y Hao, J Li, L Dan, X Wu, X Xiao, H Yang… - Journal of …, 2023 - Elsevier
Ethnic pharmacological relevance Pulmonary fibrosis (PF) is a fibrotic interstitial lung
disease caused by continuous damage and excessive repair of alveolar epithelial cells, the …

Role of cellular senescence in inflammatory lung diseases

C Xie, MMY Likun, Q Luo, J Dong - Cytokine & Growth Factor Reviews, 2023 - Elsevier
Cellular senescence, a characteristic sign of aging, classically refers to permanent cell
proliferation arrest and is a vital contributor to the pathogenesis of cancer and age-related …

Update on metabolomic findings in COPD patients

J Gea, CJ Enríquez-Rodríguez… - ERJ Open …, 2023 - Eur Respiratory Soc
COPD is a heterogeneous disorder that shows diverse clinical presentations (phenotypes
and “treatable traits”) and biological mechanisms (endotypes). This heterogeneity implies …

[HTML][HTML] Advances in cellular senescence in idiopathic pulmonary fibrosis

S Han, Q Lu, X Liu - Experimental and Therapeutic …, 2023 - spandidos-publications.com
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible and fatal interstitial lung
disease of unknown cause, with a median survival of 2‑3 years. Its pathogenesis is unclear …

[HTML][HTML] Theophylline Attenuates BLM-Induced Pulmonary Fibrosis by Inhibiting Th17 Differentiation

SJ Park, HJ Hahn, SR Oh, HJ Lee - International Journal of Molecular …, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic and refractory interstitial lung disease.
Although there are two approved drugs for IPF, they were not able to completely cure the …