Ferroptosis in pulmonary fibrosis: an emerging therapeutic target

C Wang, S Hua, L Song - Frontiers in Physiology, 2023 - frontiersin.org
In recent years, the role of ferroptosis in pulmonary fibrosis has garnered increasing interest
as a potential therapeutic target. Pulmonary fibrosis is a pathological process characterized …

The emerging roles of ferroptosis in organ fibrosis and its potential therapeutic effect

X Huang, Y Song, L Wei, J Guo, W Xu, M Li - International …, 2023 - Elsevier
Fibrosis refers to the process of excessive deposition of extracellular matrix (ECM) proteins,
eventually leading to excessive scar formation. Fibrotic diseases can occur in many organs …

Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways

H Li, X Jiang, Y Xiao, Y Zhang, W Zhang, M Doherty… - Bone Research, 2023 - nature.com
Hand osteoarthritis is a common heterogeneous joint disorder with unclear molecular
mechanisms and no disease-modifying drugs. In this study, we performed single-cell RNA …

Nanoparticle‐Based MRI‐Guided Tumor Microenvironment Heating via the Synergistic Effect of Ferroptosis and Inhibition of TGF‐β Signaling

R Zhou, Y Liu, Z Wang, J Lv, W Liao… - Advanced …, 2023 - Wiley Online Library
Although induction of ferroptosis and inhibition of transforming growth factor‐β (TGF‐β)
signaling are both effective ways to reform the tumor microenvironment (TME) and render …

Quercetin inhibits the progression of endometrial HEC-1-A cells by regulating ferroptosis—a preliminary study

X Li, Q Zhu, M Ma, H Guo - European Journal of Medical Research, 2022 - Springer
Background Endometrial carcinoma (EC) is one of the most common female reproductive
system tumors, which seriously threatens women's health. This preliminary study aimed to …

[HTML][HTML] Recent advances of ferroptosis in tumor: From biological function to clinical application

S Hu, Y Chu, X Zhou, X Wang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Ferroptosis is a recently recognized form of cell death with distinct features in terms of
morphology, biochemistry, and molecular mechanisms. Unlike other types of cell death …

[HTML][HTML] Iron overload triggering ECM-mediated Hippo/YAP pathway in follicle development: a hypothetical model endowed with therapeutic implications

L Xia, Y Shen, S Liu, J Du - Frontiers in Endocrinology, 2023 - frontiersin.org
Disruption of iron homeostasis plays a negative role in follicle development. The dynamic
changes in follicle growth are dependent on Hippo/YAP signaling and mechanical forces …

Ferroptosis contributes to endometrial fibrosis in intrauterine adhesions

Q Zhu, S Yao, Z Ye, P Jiang, H Wang, X Zhang… - Free Radical Biology …, 2023 - Elsevier
Intrauterine adhesions (IUA), characterized by endometrial fibrosis, is a challenging clinical
issue in reproductive medicine. We previously demonstrated that epithelial-mesenchymal …

Vitamin E stabilizes iron and mitochondrial metabolism in pulmonary fibrosis

J Chang, J Wang, B Luo, W Li, Z Xiong, C Du… - Frontiers in …, 2023 - frontiersin.org
Introduction: Pulmonary fibrosis (PF) is a fatal chronic lung disease that causes structural
damage and decreased lung function and has a poor prognosis. Currently, there is no …

Role of ferroptosis in regulating the epithelial–mesenchymal transition in pulmonary fibrosis

H Ling, H Xiao, T Luo, H Lin, J Deng - Biomedicines, 2023 - mdpi.com
Idiopathic pulmonary fibrosis is a chronic interstitial lung disease whose pathogenesis
involves a complex interaction of cell types and signaling pathways. Lung epithelial cells …