Single-cell atlases: shared and tissue-specific cell types across human organs
R Elmentaite, C Domínguez Conde, L Yang… - Nature Reviews …, 2022 - nature.com
The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …
[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …
Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function
Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
Cell transcriptomic atlas of the non-human primate Macaca fascicularis
Studying tissue composition and function in non-human primates (NHPs) is crucial to
understand the nature of our own species. Here we present a large-scale cell transcriptomic …
understand the nature of our own species. Here we present a large-scale cell transcriptomic …
Spatial mapping of the total transcriptome by in situ polyadenylation
Spatial transcriptomics reveals the spatial context of gene expression, but current methods
are limited to assaying polyadenylated (A-tailed) RNA transcripts. Here we demonstrate that …
are limited to assaying polyadenylated (A-tailed) RNA transcripts. Here we demonstrate that …
Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration
DW McKellar, LD Walter, LT Song, M Mantri… - Communications …, 2021 - nature.com
Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …
Aging, obesity, sarcopenia and the effect of diet and exercise intervention
G Colleluori, DT Villareal - Experimental gerontology, 2021 - Elsevier
The number of adults 65 years and older is increasing worldwide and will represent the 20%
of the population by 2030. Half of them will suffer from obesity. The decline in muscle mass …
of the population by 2030. Half of them will suffer from obesity. The decline in muscle mass …
Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution
Skeletal muscle fibers express distinct gene programs during development and maturation,
but the underlying gene regulatory networks that confer stage-specific myofiber properties …
but the underlying gene regulatory networks that confer stage-specific myofiber properties …
Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. We
investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and …
investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and …
Traumatic muscle injury
Traumatic muscle injury represents a collection of skeletal muscle pathologies caused by
trauma to the muscle tissue and is defined as damage to the muscle tissue that can result in …
trauma to the muscle tissue and is defined as damage to the muscle tissue that can result in …