Chronic pain affects more than 50 million Americans. Treatments remain inadequate, in
large part, because the pathophysiological mechanisms underlying the development of …

Background The treatment of neuropathic pain remains a major unmet need that the
development of personalized and refined treatment strategies may contribute to address …

Neuropathic pain (NP) is a chronic pain condition resulting from a lesion or disease in the
somatosensory nervous system. The aim of this study was to investigate the metabolome in …

Recent scientific evidence suggests that chronic pain phenotypes are reflected in
metabolomic changes. However, problems associated with chronic pain, such as sleep …

Despite the worldwide prevalence and huge burden of pain, pain is an undertreated
phenomenon. Currently used analgesics have several limitations regarding their efficacy …

In the last decade, several studies have demonstrated Cutibacterium acnes colonization in
intervertebral discs (IVDs) in patients with lumbar disc degeneration (LDD) and low back …

Objective To identify metabolites in presurgical blood associated with risk of persistent
postsurgical pelvic pain 1 year after endometriosis surgery in adolescent and young adult …

Lappaconitine (LA) is a C-18 diterpene alkaloid isolated from Aconitum sinomontanum
Nakai that has been shown to relieve mild to moderate discomfort. Various researchers have …

Abdominal pain in patients with inflammatory bowel diseases (IBDs) is very common and up
to 80% of patients experience some type of acute pain as a result of inflammation and/or …

Background: Persistent postsurgical neuropathic pain (PPSNP) can occur after
intraoperative damage to somatosensory nerves, with a prevalence of 29–57% in breast …