The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

Glaucoma, one of the leading causes of irreversible blindness worldwide, is a complex and
heterogenous disease. While environmental factors are important, it is well-recognized that …

Diabetes mellitus-induced hyperglycemia is responsible for multiple pathological ocular
alternations from vasculopathy to biomechanical dyshomeostasis. Biomechanical …

In this study we used a spatial transcriptomics approach to identify genes specifically
associated with either high or low outflow regions in the trabecular meshwork (TM) that …

Glaucoma is a highly heritable disease, and myocilin was the first identified causal and most
common pathogenic gene in glaucoma. Serine-to-proline mutation at position 341 of …

The axons of retinal ganglion cells (RGCs) form the optic nerve, transmitting visual
information from the eye to the brain. Damage or loss of RGCs and their axons is the leading …

Low intracranial pressure (LICP)–induced translaminar cribrosa pressure difference
(TLCPD) elevation has been proven as a risk factor in glaucomatous neurodegeneration …

Viral transduction of the mouse trabecular meshwork using a variety of transgenes
associated with glaucoma generates an inducible and reproducible method for generating …

The mechanical theory of glaucoma indicates that high intraocular pressure (IOP) leads to
glaucomatous optic nerve damage. However, nearly half of primary open‐angle glaucoma …