JAK inhibitors in the treatment of atopic dermatitis
R Chovatiya, AS Paller - Journal of Allergy and Clinical Immunology, 2021 - Elsevier
Atopic dermatitis (AD) is a chronic inflammatory skin disorder associated with heterogenous
presentation and often immense patient burden. Safe, targeted treatment options are …
presentation and often immense patient burden. Safe, targeted treatment options are …
Systemic immunomodulatory treatments for atopic dermatitis: update of a living systematic review and network meta-analysis
Importance Systemic treatments for atopic dermatitis are being evaluated primarily in
placebo-controlled trials; network meta-analysis can provide relative efficacy and safety …
placebo-controlled trials; network meta-analysis can provide relative efficacy and safety …
European guideline (EuroGuiDerm) on atopic eczema: part I–systemic therapy
A Wollenberg, M Kinberger, B Arents… - Journal of the …, 2022 - Wiley Online Library
The evidence‐and consensus‐based guideline on atopic eczema was developed in
accordance with the EuroGuiDerm Guideline and Consensus Statement Development …
accordance with the EuroGuiDerm Guideline and Consensus Statement Development …
European guideline (EuroGuiDerm) on atopic eczema–part II: non‐systemic treatments and treatment recommendations for special AE patient populations
A Wollenberg, M Kinberger, B Arents… - Journal of the …, 2022 - Wiley Online Library
The evidence‐and consensus‐based guideline on atopic eczema was developed in
accordance with the EuroGuiDerm Guideline and Consensus Statement Development …
accordance with the EuroGuiDerm Guideline and Consensus Statement Development …
Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): results from …
K Reich, HD Teixeira, M de Bruin-Weller, T Bieber… - The Lancet, 2021 - thelancet.com
Background Systemic therapies are typically combined with topical corticosteroids for the
management of moderate-to-severe atopic dermatitis. Upadacitinib is an oral Janus kinase …
management of moderate-to-severe atopic dermatitis. Upadacitinib is an oral Janus kinase …
[HTML][HTML] JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …
[HTML][HTML] Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating
inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors …
inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors …
[HTML][HTML] Targeted immunotherapy for autoimmune disease
SM Jung, WU Kim - Immune network, 2022 - ncbi.nlm.nih.gov
In the past few decades, biological drugs and small molecule inhibitors targeting
inflammatory cytokines, immune cells, and intracellular kinases have become the standard …
inflammatory cytokines, immune cells, and intracellular kinases have become the standard …
Innovation in the treatment of atopic dermatitis: emerging topical and oral Janus kinase inhibitors
C Nakashima, S Yanagihara, A Otsuka - Allergology International, 2022 - jstage.jst.go.jp
abstract Atopic dermatitis (AD) is characterized by chronic, eczematous, severe pruritic skin
lesions. The knowledge on the pathogenesis of AD is driving the development of new drugs …
lesions. The knowledge on the pathogenesis of AD is driving the development of new drugs …
Comparative efficacy and safety of abrocitinib, baricitinib, and upadacitinib for moderate‐to‐severe atopic dermatitis: a network meta‐analysis
H Wan, H Jia, T Xia, D Zhang - Dermatologic Therapy, 2022 - Wiley Online Library
Janus kinase (JAK) inhibitors have become promising treatments for atopic dermatitis (AD),
however no study directly comparing JAK inhibitors with each other has been reported. We …
however no study directly comparing JAK inhibitors with each other has been reported. We …