Multidrug resistancerelated protein 1 (MRP1), an ATPbinding cassette transporter encod ed
by the ABCC1 gene, is expressed in many tissues, and functions as an effiux transporter for …

Human multidrug resistance protein 1 (MRP1) is a member of the ATP-binding cassette
(ABC) transport superfamily which also includes human multidrug resistance 1 (MDR1) …

Multidrug resistance-associated protein 1 (MRP1) was originally shown to confer resistance
of human tumor cells to a broad range of natural product anticancer drugs. MRP1 has also …

ATP binding cassette (ABC) transporters are involved in drug absorption, distribution and
elimination. They also mediate multidrug resistance in cancer cells. Isoflavones, such as …

Background: MRP1 is a key multidrug resistance ATP-binding Cassette (ABC) transporter in
tumor cells. A functionally important signature motif is conserved within all ABC domains …

Activating mutations in different domains of the ABCC8 gene-coded sulfonylurea receptor 1
(SUR1) cause neonatal diabetes. Here we show that a diabetogenic mutation in an …

The ATP-binding cassette (ABC) transporter genes are ubiquitous in the genomes of all
vertebrates so far studied. The human ABC transporter superfamily contains 48 genes …

Localization of ATP-binding cassette transporter isoform C1 (ABCC1) to the basolateral
membrane of polarized cells is crucial for export of a variety of cellular metabolites; however …

ABCC1 is a member of the ATP-binding Cassette super family of transporters, actively
effluxes xenobiotics from cells. Clinically, ABCC1 expression is linked to cancer multidrug …

ABCC6 is a member of the C subfamily of ATP-binding cassette transporters whose
mutations are correlated to Pseudoxanthoma elasticum, an autosomal recessive …