The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both
normal and pathological angiogenesis, has revealed innovative therapeutic approaches in …

Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …

BACKGROUND: There has been a dramatic increase in the off-label use of ophthalmic
timolol maleate, a β-blocker used for infantile hemangioma (IH) treatment as a topical …

OBJECTIVE: Timolol maleate 0.5% gel is a safe and effective medication for treating
superficial infantile hemangiomas (IHs) in infants with a median age of 9 weeks. METHODS …

Eye diseases and injuries constitute a significant clinical problem worldwide. Safe and
effective delivery of drugs to the eye is challenging mostly due to the presence of ocular …

Glaucoma is a progressive ocular syndrome characterized by degeneration of the optic
nerve and irreversible visual field loss. Elevated intraocular pressure (IOP) is the main risk …

Background Medication use is a potentially modifiable risk factor for falling; psychotropic and
cardiovascular drugs have been indicated as main drug groups that increase fall risk …

Background Topical use of timolol for infantile hemangiomas has recently emerged with
promising results. It is unknown whether topical β‐blockers act locally or if their effect is …

The objective of this study was to evaluate ocular tolerance, safety, and effect on intraocular
pressure (IOP) of a topically administered small interfering RNA; SYL040012, on healthy …

Introduction: It is generally believed that topical administration of eye drops safeguards
against harmful systemic effects. However, about 80% of the drug in the ophthalmic products …