Intervertebral disc degeneration and how it leads to low back pain

AD Diwan, J Melrose - Jor Spine, 2023 - Wiley Online Library
The purpose of this review was to evaluate data generated by animal models of
intervertebral disc (IVD) degeneration published in the last decade and show how this has …

An update on animal models of intervertebral disc degeneration and low back pain: exploring the potential of artificial intelligence to improve research analysis and …

M Alini, AD Diwan, WM Erwin, CB Little, J Melrose - JOR spine, 2023 - Wiley Online Library
Animal models have been invaluable in the identification of molecular events occurring in
and contributing to intervertebral disc (IVD) degeneration and important therapeutic targets …

Machine Learning Prediction of Flavonoid Cocrystal Formation Combined with Experimental Validation

H Yue, J Wang - Industrial & Engineering Chemistry Research, 2023 - ACS Publications
This study established a flavonoid cocrystal database, and four machine learning models
[support vector machine (SVM), random forest (RF), logistic regression (LR), and artificial …

Natural products for the treatment of depression: Insights into signal pathways influencing the hypothalamic–pituitary–adrenal axis

J Liu, T Meng, C Wang, W Cheng, Q Zhang, G Cheng - Medicine, 2023 - journals.lww.com
Depression, a prevalent psychiatric malady, afflicts a substantial global demographic,
engendering considerable disease burden due to its elevated morbidity and mortality rates …

A practical and economic route for regioselective cyclization of β-phenoxyl ynones to flavonoid derivatives

GQ Zhang, F Yang, WS Chen, X Zhao, T Wang… - Green …, 2024 - pubs.rsc.org
A green, efficient and highly regioselective synthesis of flavonoids and their derivatives from
β-phenoxyl ynones using wet 1, 3-propanediol as reaction medium was developed, without …

[HTML][HTML] Mechanism insights into the pleiotropic effects of nobiletin as a potential therapeutic agent on non-alcoholic fatty liver disease (NAFLD)

Q Ran, Q Gan, Y Zhu, L Song, L Shen, X Duan… - Biomedicine & …, 2024 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases and is
emerging as one of the fastest-growing causes of liver-related deaths worldwide. It is …

Green and efficient extraction process of flavonoids from sea buckthorn fruits by natural deep eutectic solvents aided with ultrasound

P Ma, Z Li, Y Jin, J Zuo, Y Zhang, A Dong, D Xiao… - Microchemical …, 2024 - Elsevier
In recent years, with the advantages of environment friendly, natural deep eutectic solvents
(NADES) have been gradually applied for the extracting bioactive compounds from natural …

Extraction of Cynaroside from Honeysuckle by Nonionic Surfactant-Mediated Aqueous Extraction with Cloud Point Enrichment and Purification by Metal Complexation

W Zhu, H Wang, C Tang, B Wang, J Liu, Y Zu… - Food and Bioprocess …, 2024 - Springer
Honeysuckle is rich in cynaroside (Cy), but its extraction and purification are difficult due to
its poor solubility in water. Therefore, nonionic surfactants were used to extract Cy from …

[HTML][HTML] SOS! Hydrogen Sulfide Enhances the Flavonoid Early Warning System in Rice Plants to Cope with Thiocyanate Pollution

P Tian, YX Feng, YH Li - Toxics, 2024 - mdpi.com
The presence of thiocyanate (SCN−) in irrigation water has adverse effects on both plant
growth and crop output. Hydrogen sulfide (H2S) is an important gaseous signaling molecule …

Fresh bamboo juice regulates the diversity of intestinal microflora in mice by promoting the function of ILC2 cells to mediate intestinal protection

J Hu, C Zuo, Y Xiao, X Niu, P Zeng, X He… - International …, 2024 - Elsevier
Background and aim Ulcerative colitis (UC) is a growing global health concern, with current
treatments facing challenges like drug dependence and side effects. Fresh bamboo juice …