Current state and future directions in the therapy of ALS

L Tzeplaeff, S Wilfling, MV Requardt, M Herdick - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …

New developments and opportunities in drugs being trialed for amyotrophic lateral sclerosis from 2020 to 2022

JS Jiang, Y Wang, M Deng - Frontiers in pharmacology, 2022 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that
primarily affects motor neurons in the brain and spinal cord. In the recent past, there have …

[HTML][HTML] Masitinib: The promising actor in the next season of the Amyotrophic Lateral Sclerosis treatment series

AHME Ketabforoush, R Chegini, S Barati… - Biomedicine & …, 2023 - Elsevier
Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with high
mortality and morbidity rate affecting both upper and lower motor neurons (MN). Muscle …

Microglial crosstalk with astrocytes and immune cells in amyotrophic lateral sclerosis

M Calafatti, G Cocozza, C Limatola… - Frontiers in …, 2023 - frontiersin.org
In recent years, biomedical research efforts aimed to unravel the mechanisms involved in
motor neuron death that occurs in amyotrophic lateral sclerosis (ALS). While the main …

Microglia and astrocytes in amyotrophic lateral sclerosis: disease-associated states, pathological roles, and therapeutic potential

J You, MMM Youssef, JR Santos, J Lee, J Park - Biology, 2023 - mdpi.com
Simple Summary Amyotrophic lateral sclerosis (ALS) is a disease characterized by the
death of motor neurons that results in progressive muscle weakness and paralysis …

Therapeutic targeting of ALS pathways: Refocusing an incomplete picture

NJ Maragakis, M de Carvalho… - Annals of Clinical and …, 2023 - Wiley Online Library
Numerous potential amyotrophic lateral sclerosis (ALS)‐relevant pathways have been
hypothesized and studied preclinically, with subsequent translation to clinical trial. However …

Oxidative stress in the brain and retina after traumatic injury

AK Ryan, W Rich, MA Reilly - Frontiers in neuroscience, 2023 - frontiersin.org
The brain and the retina share many physiological similarities, which allows the retina to
serve as a model of CNS disease and disorder. In instances of trauma, the eye can even …

Status of ALS treatment, insights into therapeutic challenges and dilemmas

M Khamaysa, PF Pradat - Journal of Personalized Medicine, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is an extremely heterogeneous disease of motor
neurons that eventually leads to death. Despite impressive advances in understanding the …

Macrophage migration inhibitor factor (MIF): potential role in cognitive impairment disorders

L Zeng, P Hu, Y Zhang, M Li, S Li, A Luo - Cytokine & Growth Factor …, 2024 - Elsevier
Macrophage migration inhibitory factor (MIF) is a cytokine in the immune system,
participated in both innate and adaptive immune responses. Except from immune cells, MIF …

Emerging clinical investigational drugs for the treatment of amyotrophic lateral sclerosis

L Martinez-Gonzalez, A Martinez - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder caused by
motoneuron death with a median survival time of 3–5 years since disease onset. There are …