Ovarian cancer is the second most common cause of gynecologic cancer death in women
around the world. The outcomes are complicated, because the disease is often diagnosed …

Ovarian cancer is the leading cause of gynecological cancer-related mortality globally. The
majority of ovarian cancer patients suffer from relapse after standard of care therapies and …

Background Platinum-based chemotherapy is the foundation of treatment for platinum-
sensitive recurrent ovarian cancer, but has substantial toxicity. Bevacizumab and …

Importance To date, single-agent programmed cell death 1 protein 1 (PD-1)/programmed
death ligand 1 (PD-L1) immune checkpoint blockade has shown limited activity in recurrent …

Despite the progress made during the last two decades in the surgery and chemotherapy of
ovarian cancer, more than 70% of advanced patients are with recurrent cancer and …

Chronic stress is well-known to cause physiological distress that leads to body balance
perturbations by altering signaling pathways in the neuroendocrine and sympathetic …

Neovascular age-related macular degeneration (exudative or wet AMD) is a prevalent,
progressive retinal degenerative macular disease that is characterized by …

Paracrine signaling between tumor and surrounding stromal cells is critical for the
maintenance of tumor microenvironment during ovarian cancer progression. Small …

Angiogenesis is required in cancer, including gynecological cancers, for the growth of
primary tumors and secondary metastases. Development of anti-angiogenesis therapy in …

Importance There are substantial unmet therapeutic needs in patients with platinum-
resistant recurrent ovarian cancer (PROC), and novel therapeutic strategies should be …