Novel aspects of pathogenesis and regeneration mechanisms in COPD

E Bagdonas, J Raudoniute, I Bruzauskaite… - … journal of chronic …, 2015 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD), a major cause of death and morbidity
worldwide, is characterized by expiratory airflow limitation that is not fully reversible …

Animal models of chronic obstructive pulmonary disease

M Fricker, A Deane, PM Hansbro - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: Chronic obstructive pulmonary disease (COPD) is a leading global cause of
mortality and chronic morbidity. Inhalation of cigarette smoke is the principal risk factor for …

Microbiota promotes chronic pulmonary inflammation by enhancing IL-17A and autoantibodies

K Yadava, C Pattaroni, AK Sichelstiel… - American journal of …, 2016 - atsjournals.org
Rationale: Changes in the pulmonary microbiota are associated with progressive respiratory
diseases including chronic obstructive pulmonary disease (COPD). Whether there is a …

Contribution of adaptive immunity to human COPD and experimental models of emphysema

F Kheradmand, Y Zhang, DB Corry - Physiological reviews, 2023 - journals.physiology.org
The pathophysiology of chronic obstructive pulmonary disease (COPD) and the undisputed
role of innate immune cells in this condition have dominated the field in the basic research …

The role of mitochondria and oxidative/antioxidative imbalance in pathobiology of chronic obstructive pulmonary disease

AJ Białas, P Sitarek… - Oxidative medicine …, 2016 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable
disease, characterized by persistent airflow limitation that is usually progressive and …

Tobacco smoke induced COPD/emphysema in the animal model—are we all on the same page?

M Leberl, A Kratzer, L Taraseviciene-Stewart - Frontiers in physiology, 2013 - frontiersin.org
Chronic Obstructive Pulmonary Disease (COPD) is one of the foremost causes of death
worldwide. It is primarily caused by tobacco smoke, making it an easily preventable disease …

SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment

SA Mian, K Rouault-Pierre, AE Smith, T Seidl… - Nature …, 2015 - nature.com
Despite the recent evidence of the existence of myelodysplastic syndrome (MDS) stem cells
in 5q-MDS patients, it is unclear whether haematopoietic stem cells (HSCs) could also be …

The role of CD8+ T lymphocytes in chronic obstructive pulmonary disease: a systematic review

M Williams, I Todd, LC Fairclough - Inflammation Research, 2021 - Springer
Objective and design This systematic review aims to establish the role of CD8+ T
lymphocytes in COPD. Methods Forty-eight papers published in the last 15 years were …

Animal models and mechanisms of tobacco smoke-induced chronic obstructive pulmonary disease (COPD)

P Upadhyay, CW Wu, A Pham, AA Zeki… - Journal of Toxicology …, 2023 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death
worldwide, and its global health burden is increasing. COPD is characterized by …

Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema

R You, W Lu, M Shan, JM Berlin, ELG Samuel… - elife, 2015 - elifesciences.org
Chronic inhalation of cigarette smoke is the major cause of sterile inflammation and
pulmonary emphysema. The effect of carbon black (CB), a universal constituent of smoke …