[HTML][HTML] The tobacco smoke component, acrolein, as a major culprit in lung diseases and respiratory cancers: Molecular mechanisms of acrolein cytotoxic activity

P Hikisz, D Jacenik - Cells, 2023 - mdpi.com
Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant
that seriously threatens human health and life. Due to its high reactivity, cytotoxicity and …

Dysregulation of immunity by cigarette smoking promotes inflammation and cancer: a review

Y Liu, L Lu, H Yang, X Wu, X Luo, J Shen, Z Xiao… - Environmental …, 2023 - Elsevier
Smoking is a serious global health issue. Cigarette smoking contains over 7000 different
chemicals. The main harmful components include nicotine, acrolein, aromatic hydrocarbons …

[HTML][HTML] Diet as a source of acrolein: molecular basis of aldehyde biological activity in diabetes and digestive system diseases

P Hikisz, D Jacenik - International Journal of Molecular Sciences, 2023 - mdpi.com
Acrolein, a highly reactive α, β-unsaturated aldehyde, is a compound involved in the
pathogenesis of many diseases, including neurodegenerative diseases, cardiovascular and …

Elimination of Acrolein by Disodium 5′-Guanylate or Disodium 5′-Inosinate at High Temperature and Its Application in Roasted Pork Patty

H Gu, B Si, C Yang, M Jia, Y Lu, L Lv… - Journal of Agricultural …, 2023 - ACS Publications
Acrolein (ACR) is a highly active, simple unsaturated aldehyde found in various high-
temperature processed foods. Its long-term accumulation in the human body increases the …

DNA Adducts in Cancer Chemotherapy

Y Li - Journal of Medicinal Chemistry, 2024 - ACS Publications
DNA adducting drugs, including alkylating agents and platinum-containing drugs, are
prominent in cancer chemotherapy. Their mechanisms of action involve direct interaction …

[HTML][HTML] Polyamine-Derived Aminoaldehydes and Acrolein: Cytotoxicity, Reactivity and Analysis of the Induced Protein Modifications

M Šebela, M Rašková - Molecules, 2023 - mdpi.com
Polyamines participate in the processes of cell growth and development. The degradation
branch of their metabolism involves amine oxidases. The oxidation of spermine, spermidine …

Theanine Capture of Reactive Carbonyl Species in Humans after Consuming Theanine Capsules or Green Tea

Y Zhong, C Yang, Y Lu, L Lv - Journal of Agricultural and Food …, 2024 - ACS Publications
Acrolein (ACR), methylglyoxal (MGO), and glyoxal (GO) are a class of reactive carbonyl
species (RCS), which play a crucial role in the pathogenesis of chronic and age-related …

Multi-adductomics: Advancing mass spectrometry techniques for comprehensive exposome characterization

MR Chao, YJ Chang, MS Cooke, CW Hu - TrAC Trends in Analytical …, 2024 - Elsevier
Adductomics, an emerging field within the'omics sciences, focuses on the formation and
prevalence of DNA, RNA, and protein adducts induced by endogenous and exogenous …

Capture of single or multiple reactive carbonyl species by mangiferin under high temperatures

R Du, Y Liang, B Si, C Chang, Y Lu, L Lv - Food Chemistry, 2024 - Elsevier
Reactive carbonyl species (RCS), including acrolein (ACR), methylglyoxal (MGO), and
glyoxal (GO), are typically generated in food processing and accumulate in the body for …

Levels of Urinary Mercapturic Acids of Acrolein, Methacrolein, Crotonaldehyde, and Methyl Vinyl Ketone in Relationship to Chronic Obstructive Pulmonary Disease in …

CH Wendt, RP Bowler, C Demorest… - Chemical research in …, 2023 - ACS Publications
Cigarette smoking is an established cause of chronic obstructive pulmonary disease
(COPD). Numerous studies implicate acrolein, which occurs in relatively high concentrations …