The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …

The aging process results in multiple traceable footprints, which can be quantified and used
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …

Biological age (BA) is useful for examining differences in aging rates. Nevertheless, little
consensus exists regarding optimal methods for calculating BA. The aim of this study is to …

Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and
oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …

This review article summarizes how frailty can be considered in relation to deficit
accumulation. Recalling that frailty is an age-associated, nonspecific vulnerability, we …

Background There is no criterion reference for assessing healthy ageing and this creates
difficulties when conducting and comparing research on ageing across studies. A cardinal …

Telomeres, the DNA–protein structures located at the ends of chromosomes, have been
proposed to act as a biomarker of aging. In this review, the human evidence that telomere …

Long‐term caloric restriction (CR) is a robust means of reducing age‐related diseases and
extending life span in multiple species, but the effects in humans are unknown. The low …

The identification of genes and interventions that slow or reverse aging is hampered by the
lack of non-invasive metrics that can predict the life expectancy of pre-clinical models. Frailty …

Understanding the heterogeneity in health of older adults is a compelling question in the
biology of aging. We analyzed the performance of five measures of health heterogeneity …