Glutamate and GABA in microglia-neuron cross-talk in Alzheimer's disease

GA Czapski, JB Strosznajder - International Journal of Molecular Sciences, 2021 - mdpi.com
The physiological balance between excitation and inhibition in the brain is significantly
affected in Alzheimer's disease (AD). Several neuroactive compounds and their signaling …

The role of gut microbiota in pathogenesis of Alzheimer's disease

M Bostanciklioğlu - Journal of applied microbiology, 2019 - academic.oup.com
This paper describes the effects of the gut microbiota on the pathogenesis of Alzheimer's
pathology by evaluating the current original key findings and identifying gaps in the …

[HTML][HTML] Transformative network modeling of multi-omics data reveals detailed circuits, key regulators, and potential therapeutics for Alzheimer's disease

M Wang, A Li, M Sekiya, ND Beckmann, X Quan… - Neuron, 2021 - cell.com
To identify the molecular mechanisms and novel therapeutic targets of late-onset
Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics …

Benzodiazepines in Alzheimer's disease: beneficial or detrimental effects

HM Al-Kuraishy, AI Al-Gareeb, HM Saad… - …, 2023 - Springer
Dementia is considered a clinical syndrome characterized by cognitive dysfunction and
memory loss. Alzheimer's disease (AD) is the most common type of dementia. AD is linked …

The GABAergic system as a therapeutic target for Alzheimer's disease

B Calvo‐Flores Guzmán, C Vinnakota… - Journal of …, 2018 - Wiley Online Library
Glutamatergic and cholinergic dysfunction are well‐attested features of Alzheimer's disease
(AD), progressing with other pathological indices of the disorder and exacerbating neuronal …

Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-GF/NL-GF mice

C Emre, LE Arroyo-García, KV Do, B Jun… - Communications …, 2022 - nature.com
Sustained microglial activation and increased pro-inflammatory signalling cause chronic
inflammation and neuronal damage in Alzheimer's disease (AD). Resolution of inflammation …

Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer's disease neuropathologic change

P Scaduto, JC Lauterborn, CD Cox, A Fracassi… - Acta …, 2023 - Springer
Individuals at distinct stages of Alzheimer's disease (AD) show abnormal
electroencephalographic activity, which has been linked to network hyperexcitability and …

Unsupervised excitation: GABAergic dysfunctions in Alzheimer's disease

EA Giovannetti, M Fuhrmann - Brain research, 2019 - Elsevier
Alzheimer's disease (AD) is characterized by the classical hallmarks of Aβ-deposition and
tau-pathology that are thought to ultimately lead to synapse and neuron loss. Although long …

Insights on benzodiazepines' potential in Alzheimer's disease

HM Al-Kuraishy, AI Al-Gareeb, AA Alsayegh… - Life Sciences, 2023 - Elsevier
Alzheimer's disease (AD) is the most frequent type of dementia characterized by the
deposition of amyloid beta (Aβ) plaque and tau-neurofibrillary tangles (TNTs) in the brain …

Sensory processing deficits and related cortical pathological changes in Alzheimer's disease

NK Zhang, SK Zhang, LI Zhang, HW Tao… - Frontiers in Aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily affecting
cognitive functions. However, sensory deficits in AD start to draw attention due to their high …