Introduction The upper respiratory tract is a major route of infection for COVID-19 and other
respiratory diseases. Thus, it appears logical to exploit the nose as administration site to …

Acute and chronic administration of intranasal oxytocin and vasopressin have been
extensively utilized in both animal models and human preclinical and clinical studies over …

In vitro–in vivo correlation (IVIVC) allows prediction of in vivo drug deposition from a nasally
inhaled drug based on in vitro drug measurements. In vitro measurements include physical …

Background & aims Nasal obstruction caused by nasal septal deviation is very bothersome
and, therefore, can affect the patient's emotional state. However, little is known about the …

Sino-nasal disease is appropriately treated with topical treatment, where the nasal mucosa
acts as a barrier to systemic absorption. Non-invasive nasal delivery of drugs has produced …

Spray freeze drying is an appropriate technique for producing nasally delivered inhalable
encapsulated drugs since producing microparticles with a diameter larger than 100 μm …

Chronic rhinosinusitis (CRS) impacts patients' quality of life and healthcare costs. Traditional
methods of drug delivery, such as nasal sprays and irrigation, have limited effectiveness …

Chronic rhinosinusitis (CRS) is a chronic inflammatory condition affecting the nasal and
paranasal sinuses of approximately 11.5% of the United States adult population. Oral …

Acoustic drug delivery (ADD) is an innovative method for drug delivery to the nose and
paranasal sinuses and can be used to treat chronic rhinosinusitis (CRS). The underlying …

Chronic rhinosinusitis is an upper respiratory disease during which topical drug treatment
via the nasal cavity is the most actively utilized therapeutic strategy. In addition to steroids …