Extracellular vesicles remodel tumor environment for cancer immunotherapy

M Yue, S Hu, H Sun, B Tuo, B Jia, C Chen, W Wang… - Molecular Cancer, 2023 - Springer
Tumor immunotherapy has transformed neoplastic disease management, yet low response
rates and immune complications persist as major challenges. Extracellular vesicles …

Exosome nanovesicles as potential biomarkers and immune checkpoint signaling modulators in lung cancer microenvironment: recent advances and emerging …

NA Khan, M Asim, KH Biswas, AN Alansari… - Journal of Experimental …, 2023 - Springer
Lung cancer remains the leading cause of cancer-related deaths globally, and the survival
rate remains low despite advances in diagnosis and treatment. The progression of lung …

Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis

S Qiu, L Xie, C Lu, C Gu, Y Xia, J Lv, Z Xuan… - Journal of Experimental …, 2022 - Springer
Background Liver metastasis (LM) is a major obstacle to the prognosis of gastric cancer
(GC) patients, but the molecular mechanism underlying gastric cancer liver metastasis (GC …

Smoking‐induced M2‐TAMs, via circEML4 in EVs, promote the progression of NSCLC through ALKBH5‐regulated m6A modification of SOCS2 in NSCLC cells

C Cheng, P Wang, Y Yang, X Du, H Xia, J Liu… - Advanced …, 2023 - Wiley Online Library
Lung cancer is a commonly diagnosed disease worldwide, with non‐small cell lung cancers
(NSCLCs) accounting for≈ 85% of cases. Cigarette smoke is an environmental exposure …

Delivery of engineered primary tumor-derived exosomes effectively suppressed the colorectal cancer chemoresistance and liver metastasis

C Huang, Y Zhou, X Feng, J Wang, Y Li, X Yao - ACS nano, 2023 - ACS Publications
Liver metastasis is one of the major causes of colorectal cancer (CRC)-related morbidity and
mortality. Delivering small interfering RNAs (siRNAs) or noncoding RNAs has been reported …

Monocytes educated by cancer-associated fibroblasts secrete exosomal miR-181a to activate AKT signaling in breast cancer cells

K Pakravan, M Mossahebi-Mohammadi… - Journal of Translational …, 2022 - Springer
Abstract Background Cancer-associated fibroblasts (CAFs), one of the major components of
the tumor stroma, contribute to an immunosuppressive tumor microenvironment (TME) …

The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors

K Hadiloo, S Taremi, M Heidari, A Esmaeilzadeh - Biomarker Research, 2023 - Springer
Today, adoptive cell therapy has many successes in cancer therapy, and this subject is
brilliant in using chimeric antigen receptor T cells. The CAR T cell therapy, with its FDA …

Cancer‐derived non‐coding RNAs endow tumor microenvironment with immunosuppressive properties

T Hu, R Shi, Y Gu, H Zhou, Y Fang, T Xu… - Wiley …, 2024 - Wiley Online Library
Non‐coding RNAs (ncRNAs) have attracted extensive attention due to their vital roles in
tumorigenesis and progression, especially in the immunotherapy resistance. Tumor …

Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein‐1‐H3K4me3‐mediated immune escape in oesophageal squamous …

J Liu, WY Zhou, XJ Luo, YX Chen… - Clinical and …, 2023 - Wiley Online Library
Background Predictive biomarkers for oesophageal squamous cell carcinoma (ESCC)
immunotherapy are lacking, and immunotherapy resistance remains to be addressed. The …

[HTML][HTML] Potential mechanisms of cancer-associated fibroblasts in therapeutic resistance

Z Zhao, T Li, L Sun, Y Yuan, Y Zhu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Despite continuous improvements in research and new cancer therapeutics, the goal of
eradicating cancer remains elusive because of drug resistance. For a long time, drug …