Epigenetic modifications on the chromatin do not occur in isolation. Chromatin-associated
proteins and their modification products form a highly interconnected network, and …

Tumor classification has evolved over the last decades with technical progress contributing
much to our current concepts. Among diagnostic hallmarks, novelties were immunostaining …

Over the past thirty years, the importance of chemokines and their seven-transmembrane G
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …

Currently, most men with infertility cannot be given an aetiology, which reflects a lack of
knowledge around gamete production and how it is affected by genetics and the …

Epigenetic mechanisms are essential to establish and safeguard cellular identities in
mammals. They dynamically regulate the expression of genes, transposable elements and …

An expanding range of genetic syndromes are characterized by genome‐wide disruptions in
DNA methylation profiles referred to as episignatures. Episignatures are distinct, highly …

Disruption of cell division cycle associated 7 (CDCA7) has been linked to aberrant DNA
hypomethylation, but the impact of DNA methylation loss on transcription has not been …

Many different lifestyle factors and chemicals present in the environment are a threat to the
reproductive tracts of humans. The potential for parental preconception exposure to alter …

Rare diseases (RDs), more than 80% of which have a genetic origin, collectively affect
approximately 350 million people worldwide. Progress in next-generation sequencing …

Sculpting the epigenome with a combination of histone modifications and transcription factor
occupancy determines gene transcription and cell fate specification. Here, we first develop …