The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

The epithelial adherens junction is an E-cadherin-based complex that controls tissue
integrity and is stabilized at the plasma membrane by p120-catenin (p120, also known as …

DNA methylation is an essential epigenetic mark. Three classes of mammalian proteins
recognize methylated DNA: MBD proteins, SRA proteins and the zinc-finger proteins Kaiso …

The molecular basis underlying fetal programming in response to maternal nutrition remains
unclear. Herein, we investigated the regulatory relationships between genes in fetal …

Wnts are conserved, secreted signaling proteins that can influence cell behavior by
stabilizing β-catenin. Accumulated β-catenin enters the nucleus, where it physically …

Methylated DNA can be specifically recognized by a set of proteins called methyl-CpG-
binding proteins (MBPs), which belong to three different structural families in mammals: the …

The arrival of multicellularity in evolution facilitated cell–cell signaling in conjunction with
adhesion. As the ectodomains of cadherins interact with each other directly in trans (as well …

The covalent DNA modification of cytosine at position 5 (5-methylcytosine; 5mC) has
emerged as an important epigenetic mark most commonly present in the context of CpG …

DNA methylation is a stable epigenetic mark in plant and vertebrate genomes; it is
implicated in regulation of higher order chromatin structure, maintenance of genome …

In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin,
which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and …