Genetic studies of Wnt11 have revealed many insights into the roles and regulation of
Wnt11, particularly during development. New tools to study Wnt11 have recently become …

ABSTRACT DNA methylation is an epigenetically inherited chemical modification that is
associated with transcriptional silencing and is essential for mammalian development. The …

Members of the catenin family were first isolated complexed with the cytoplasmic domains of
cadherins at cell-cell junctions, and this relationship is considered one of the defining …

Cell–cell junctions continue to capture the interest of cell and developmental biologists, with
an emerging area being the molecular means by which junctional signals relate to gene …

Kaiso is a BTB/POZ transcription factor that is ubiquitously expressed in multiple cell types
and functions as a transcriptional repressor and activator. Little is known about Kaiso …

Background DNA methylation and repressive histone modifications cooperate to silence
promoters. One mechanism by which regions of methylated DNA could acquire repressive …

The functions of many organs depend on the generation of an epithelium. The transition
from a set of loosely connected nonpolarized cells to organized sheets of closely associated …

ABSTRACT DNA methylation on CpGs regulates transcription in mammals, both by
decreasing the binding of methylation-repelled factors and by increasing the binding of …

Kaiso is a member of the BTB/POZ zinc finger family, which is involved in cancer
progression, cell cycle control, apoptosis, and WNT signaling. Depending on promoter …

p120-catenin is an E-cadherin-associated protein that modulates E-cadherin function and
stability. In response to Wnt3a, p120-catenin is phosphorylated at Ser268 and Ser269 …