Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …

Increased risk of colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients has
been attributed to long-standing chronic inflammation, with the contribution of genetic …

Nrf2 and NF-κB are important regulators of the response to oxidative stress and
inflammation in the body. Previous pharmacological and genetic studies have confirmed …

Smoking is a serious global health issue. Cigarette smoking contains over 7000 different
chemicals. The main harmful components include nicotine, acrolein, aromatic hydrocarbons …

Background & aims Helicobacter pylori infection is the predominant risk factor for gastric
cancer. RAS protein activator like 2 (RASAL2) is considered a double-edged sword in …

Abstract Ethnopharmacological relevance Dandelion (Taraxacum officinale Weber ex FH
Wigg.), as a garden weed grown globally, has long been consumed as a therapeutic herb …

Dysregulation of transcription factors has been implicated in a variety of human diseases.
However, these proteins have traditionally been regarded as undruggable and only a …

Christensenellaceae is a family of subdominant commensal bacteria found in humans. It is
thought to play an important role in gut health by maintaining microbial symbiosis. Indeed …

Tumor-induced host wasting and mortality are general phenomena across species. Many
groups have previously demonstrated endocrinal impacts of malignant tumors on host …