Hypoxia is an important feature of the tumor microenvironment, and is closely associated
with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these …

Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and
oxygen supply to the tumor cells through the decrease of the vascular network and the …

Angiogenesis is the process through which novel blood vessels are formed from pre-existing
ones and it is involved in both physiological and pathological processes of the body …

Tumor associated macrophages (TAMs) are the most frequent immune cells within tumor
microenvironment (TME). There is growing evidence that TAMs are involved in tumor …

Cancer treatment has been always considered one of the most critical and vital themes of
clinical issues. Many approaches have been developed, depending on the type and the …

Cancer is one of the leading causes of death globally, associated with multifactorial
pathophysiological components. In particular, genetic mutations, infection or inflammation …

Gene therapy is the administration of foreign genomic material into the host tissue to modify
the expression of a gene product or to change the biological properties of cells for …

Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth leading
malignancy worldwide. OSCC is an aggressive tumor and its prognosis has exhibited little …

Angiogenesis is involved in physiological and pathological processes in the body. Tumor
angiogenesis is a key factor associated with tumor growth, progression, and metastasis …

Selenium (Se) acts as an essential trace element in the human body due to its unique
biological functions, particularly in the oxidation-reduction system. Although several clinical …