Selenium is an essential microelement required for a number of biological functions.
Selenium—and more specifically the amino acid selenocysteine—is present in at least 25 …

Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

Selenium is a trace mineral that is essential for health. After being obtained from food and
taken up by the liver, selenium performs various physiological functions in the body in the …

The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators
in the human body. Its central function involves the reduction of complex hydroperoxides into …

Non-alcoholic fatty liver disease (NAFLD) is related to a dysregulation of mitophagy, a
process that is not fully understood. Parkin-related mitophagy can sustain mitochondrial …

Selenium (Se) is one of the essential trace elements that plays a biological role in the body,
mainly in the form of selenoproteins. Selenoproteins can be involved in the regulation of …

Abstract Mercuric chloride (HgCl 2), a heavy metal compound, causes neurotoxicity of
animals and humans. Selenium (Se) antagonizes heavy metal-induced organ damage with …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by chronic
neuroinflammation with amyloid beta-protein deposition and hyperphosphorylated tau …

The brain has a very high oxygen consumption rate and is particularly sensitive to oxidative
stress. It is also the last organ to suffer from a loss of selenium (Se) in case of deficiency. Se …

Selenopeptides are promising candidates for intervening in neuroinflammation; however,
the key role of selenium (Se) in selenopeptides remains poorly understood. To address this …