Castration-resistant prostate cancer (CRPC), especially metastatic castration-resistant
prostate cancer (mCRPC) is one of the most prevalent malignancies and main cause of …

Lineage plasticity, the ability of cells to transition from one committed developmental
pathway to another, has been proposed as a source of intratumoural heterogeneity and of …

Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and
represents the major therapeutic target for treating metastatic prostate cancer (mPC) …

From a clinical, morphological and molecular perspective, prostate cancer is a
heterogeneous disease. Primary prostate cancers are often multifocal, having …

During the past 10 years, preclinical studies implicating sustained androgen receptor (AR)
signalling as the primary driver of castration-resistant prostate cancer (CRPC) have led to …

Altered lipid metabolism is increasingly recognized as a signature of cancer cells. Enabled
by label-free Raman spectromicroscopy, we performed quantitative analysis of lipogenesis …

Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Purpose: Clinical features characteristic of small-cell prostate carcinoma
(SCPC),“anaplastic,” often emerge during the progression of prostate cancer. We sought to …

Prostate cancer (PCa) metastasizes selectively to bone through unknown mechanisms. In
the current study, we identified exosome-mediated transfer of pyruvate kinase M2 (PKM2) …

The practice of radical prostatectomy for treating prostate cancer has evolved remarkably
since its general introduction around 1900. Initially described using a perineal approach, the …