[HTML][HTML] Systemic scleroderma—definition, clinical picture and laboratory diagnostics

A Kowalska-Kępczyńska - Journal of Clinical Medicine, 2022 - mdpi.com
(1) Background: Scleroderma (Sc) is a rare connective tissue disease classified as an
autoimmune disorder. The pathogenesis of this disease is not fully understood.(2) Methods …

[HTML][HTML] When natural antibodies become pathogenic: autoantibodies targeted against G protein-coupled receptors in the pathogenesis of systemic sclerosis

R Akbarzadeh, A Müller, JY Humrich… - Frontiers in …, 2023 - frontiersin.org
Systemic sclerosis (SSc) is a chronic, multisystem connective tissue, and autoimmune
disease with the highest case-specific mortality and complications among rheumatic …

Treatable traits in systemic sclerosis

F Amati, G Bongiovanni, A Tonutti, F Motta… - Clinical Reviews in …, 2023 - Springer
Systemic sclerosis (SSc) is a chronic systemic disease within the spectrum of connective
tissue diseases, specifically characterized by vascular abnormalities and inflammatory and …

Significant gastrointestinal unmet needs in patients with systemic sclerosis: Insights from a large international patient survey

G Bandini, A Alunno, B Ruaro, I Galetti… - …, 2024 - academic.oup.com
DEAR EDITOR, The gastrointestinal (GI) tract is affected in the vast majority (> 90%) of
patients with SSc and is associated with significant disease-related morbidity and mortality …

Gastroparesis in systemic sclerosis: a detailed analysis using whole-gut scintigraphy

B Adler, LK Hummers, PJ Pasricha… - Rheumatology, 2022 - academic.oup.com
Objectives Gastroparesis is a common complication of SSc. We sought to determine the
degree of overlap between gastroparesis and dysmotility in other areas of the gut, correlate …

[HTML][HTML] Association between systemic sclerosis and risk of cerebrovascular and cardiovascular disease: a meta-analysis

IW Chen, WT Wang, YC Lai, CM Lin, PH Liu, SZ Wu… - Scientific Reports, 2024 - nature.com
We aimed to evaluate the association between systemic sclerosis (SSc) and major
cerebrovascular/cardiovascular risks through a systematic approach. Databases were …

Severity and impact of digestive impairment perceived by patients with systemic sclerosis: a cross-sectional study

L Cano-García, R Redondo-Rodríguez… - BMJ open, 2024 - bmjopen.bmj.com
Objectives To describe the severity and impact of gastrointestinal involvement in patients
with systemic sclerosis (SSc) and identify associated factors. Patients and methods Non …

Clinical significance of the anti-Nucleolar Organizer Region 90 antibodies (NOR90) in systemic sclerosis: Analysis of the European Scleroderma Trials and Research …

A Dima, MC Vonk, A Garaiman, BE Kersten… - European Journal of …, 2024 - Elsevier
Abstract Background The anti-Nucleolar Organizer Region 90 antibodies (NOR90) are rare
antinuclear antibodies (ANA) reported in systemic sclerosis (SSc). Especially due to low …

[HTML][HTML] Systemic sclerosis associated with primary sclerosing cholangitis and hyperthyroidism: a case report

A Ghassa, H Kilani, T Alsuliman - Annals of Medicine and …, 2023 - journals.lww.com
The association between systemic sclerosis and other immune-mediated diseases such as
primary sclerosing cholangitis and hyperthyroidism should be suspected in case the patient …

Connective tissue disorders and the gut

A Fikree - Medicine, 2024 - Elsevier
Gastrointestinal (GI) symptoms are common in both inflammatory and non-inflammatory
connective tissue disorders and can involve any part of the GI tract from mouth to anus …