Unraveling the interplay between RAS/RAF/MEK/ERK signaling pathway and autophagy in cancer: From molecular mechanisms to targeted therapy
Y Huang, Y Zhen, Y Chen, S Sui, L Zhang - Biochemical Pharmacology, 2023 - Elsevier
Abstract RAS/RAF/MEK/ERK signaling pathway is one of the most important pathways of
Mitogen-activated protein kinases (MAPK), which widely participate in regulating cell …
Mitogen-activated protein kinases (MAPK), which widely participate in regulating cell …
[HTML][HTML] The Role of Activation of PI3K/AKT/mTOR and RAF/MEK/ERK Pathways in Aggressive Pituitary Adenomas—New Potential Therapeutic Approach—A …
A Derwich, M Sykutera, B Bromińska, B Rubiś… - International Journal of …, 2023 - mdpi.com
Pituitary tumors (PT) are mostly benign, although occasionally they demonstrate aggressive
behavior, invasion of surrounding tissues, rapid growth, resistance to conventional …
behavior, invasion of surrounding tissues, rapid growth, resistance to conventional …
[HTML][HTML] Radioiodine-refractory thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance
H Shen, R Zhu, Y Liu, Y Hong, J Ge, J Xuan… - Drug Resistance …, 2023 - Elsevier
Radioiodine refractory differentiated thyroid cancer (RAIR-DTC) is difficult to treat with
radioactive iodine because of the absence of the sodium iodide transporter (NIS) in the …
radioactive iodine because of the absence of the sodium iodide transporter (NIS) in the …
[HTML][HTML] The new insights into autophagy in thyroid cancer progression
YB Shi, SY Chen, RB Liu - Journal of Translational Medicine, 2023 - Springer
In recent decades, the incidence of thyroid cancer keeps growing at a shocking rate, which
has aroused increasing concerns worldwide. Autophagy is a fundamental and ubiquitous …
has aroused increasing concerns worldwide. Autophagy is a fundamental and ubiquitous …
Advances in the molecular mechanism and targeted therapy of radioactive-iodine refractory differentiated thyroid cancer
L Zhang, Z Li, M Zhang, H Zou, Y Bai, Y Liu, J Lv, L Lv… - Medical Oncology, 2023 - Springer
Most patients with differentiated thyroid cancer have a good prognosis after radioactive
iodine-131 treatment, but there are still a small number of patients who are not sensitive to …
iodine-131 treatment, but there are still a small number of patients who are not sensitive to …
[HTML][HTML] CD73 mitigates ZEB1 expression in papillary thyroid carcinoma
S Vedovatto, FD Oliveira, LC Pereira… - Cell Communication and …, 2024 - Springer
Background ZEB1, a core transcription factor involved in epithelial-mesenchymal transition
(EMT), is associated with aggressive cancer cell behavior, treatment resistance, and poor …
(EMT), is associated with aggressive cancer cell behavior, treatment resistance, and poor …
Cytoskeletal activation of NHE1 regulates cell volume and DNA methylation
Mammalian cells can rapidly respond to osmotic and hydrostatic pressure imbalances
during an environmental change, generating large fluxes of water and ions that alter cell …
during an environmental change, generating large fluxes of water and ions that alter cell …
[HTML][HTML] Non-apoptotic programmed cell death in thyroid diseases
F Ji, X Qiu - Pharmaceuticals, 2022 - mdpi.com
Thyroid disorders are among the most common endocrinological conditions. As the
prevalence of thyroid diseases increases annually, the exploration of thyroid disease …
prevalence of thyroid diseases increases annually, the exploration of thyroid disease …
Haizao Yuhu decoctions including three species of glycyrrhiza protected against propylthiouracil-induced goiter with hypothyroidism in rats via the AMPK/mTOR …
N Li, M Li, L Xiu, W Liao, Y Ren, H Liu, S Chen… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Glycyrrhiza and sargassum are among the 18
incompatible medicaments according to traditional Chinese medicine (TCM) theory …
incompatible medicaments according to traditional Chinese medicine (TCM) theory …
[HTML][HTML] 铁死亡在肝脏疾病中的作用及治疗策略
王家琪, 李惠怡, 黄于乔, 翁琦青, 王桂香, 兰天 - 药学学报, 2022 - html.rhhz.net
调节性细胞死亡的发现使人类在疾病治疗领域取得了新的突破. 作为近十年来新发现的一种调节
性细胞死亡, 铁死亡的显著特点是细胞内铁离子的异常升高和细胞膜脂质的过氧化破损 …
性细胞死亡, 铁死亡的显著特点是细胞内铁离子的异常升高和细胞膜脂质的过氧化破损 …