Associations between findings from myelin water imaging and cognitive performance among individuals with multiple sclerosis

S Abel, I Vavasour, LE Lee, P Johnson… - JAMA network …, 2020 - jamanetwork.com
Importance Cognitive impairment is a debilitating symptom of multiple sclerosis (MS) that
affects up to 70% of patients. An improved understanding of the underlying pathology of MS …

Region‐specific impairment of the cervical spinal cord (SC) in amyotrophic lateral sclerosis: A preliminary study using SC templates and quantitative MRI (diffusion …

H Rasoanandrianina, AM Grapperon… - NMR in …, 2017 - Wiley Online Library
In this preliminary study, our objective was to investigate the potential of high‐resolution
anatomical imaging, diffusion tensor imaging (DTI) and conventional/inhomogeneous …

Combining quantitative susceptibility mapping with automatic zero reference (QSM0) and myelin water fraction imaging to quantify iron-related myelin damage in …

Y Yao, TD Nguyen, S Pandya… - American Journal …, 2018 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: A hyperintense rim on susceptibility in chronic MS lesions
is consistent with iron deposition, and the purpose of this study was to quantify iron-related …

T2prep three‐dimensional spiral imaging with efficient whole brain coverage for myelin water quantification at 1.5 tesla

TD Nguyen, C Wisnieff, MA Cooper… - Magnetic resonance …, 2012 - Wiley Online Library
Quantitative assessment of myelination is important for characterizing tissue damage and
evaluating response to therapy in white matter diseases such as multiple sclerosis …

[HTML][HTML] Brain and cord myelin water imaging: a progressive multiple sclerosis biomarker

S Kolind, A Seddigh, A Combes, B Russell-Schulz… - NeuroImage: Clinical, 2015 - Elsevier
Objectives Conventional magnetic resonance imaging (MRI) is used to diagnose and
monitor inflammatory disease in relapsing remitting (RR) multiple sclerosis (MS). In the less …

Microstructure of human corpus callosum across the lifespan: regional variations in axon caliber, density, and myelin content

JD Lynn, C Anand, M Arshad, R Homayouni… - Cerebral …, 2021 - academic.oup.com
The myeloarchitecture of the corpus callosum (CC) is characterized as a mosaic of distinct
differences in fiber density of small-and large-diameter axons along the anterior–posterior …

GAS6 enhances repair following cuprizone-induced demyelination

V Tsiperson, X Li, GJ Schwartz, CS Raine… - PLoS …, 2010 - journals.plos.org
Growth arrest-specific protein 6 (gas6) activities are mediated through the Tyro3, Axl, and
Mer family of receptor tyrosine kinases. Gas6 is expressed and secreted by a wide variety of …

[HTML][HTML] Understanding disease processes in multiple sclerosis through magnetic resonance imaging studies in animal models

N Nathoo, VW Yong, JF Dunn - NeuroImage: Clinical, 2014 - Elsevier
There are exciting new advances in multiple sclerosis (MS) resulting in a growing
understanding of both the complexity of the disorder and the relative involvement of grey …

Using myelin water imaging to link underlying pathology to clinical function in multiple sclerosis: A scoping review

EM Edwards, W Wu, NE Fritz - Multiple Sclerosis and Related Disorders, 2022 - Elsevier
Background Multiple sclerosis (MS) symptoms and pathology are heterogenous and
complex. Identifying links between MS-related pathology (ie, myelin damage) and …

Validating myelin water imaging with transmission electron microscopy in a rat spinal cord injury model

HSM Chen, N Holmes, J Liu, W Tetzlaff, P Kozlowski - Neuroimage, 2017 - Elsevier
Myelin content is an important marker for neuropathology and MRI generated myelin water
fraction (MWF) has been shown to correlate well with myelin content. However, because …