Objective Progressive myelopathy causes severe handicap in men with
adrenomyeloneuropathy (AMN), an X-linked disorder due to ABCD1 pathogenic variants. At …

Even though MRI visualization of white matter lesions is pivotal for the diagnosis and
management of multiple sclerosis (MS), the issue of detecting diffuse brain tissue damage …

Objective Considering demyelination is the pathological hallmark of multiple sclerosis (MS),
reducing demyelination and/or promoting remyelination is a practical therapeutic strategy to …

Purpose To monitor the spontaneous recovery of cervical spinal cord injury (SCI) using
longitudinal multiparametric MRI methods. Methods Quantitative MRI imaging including …

Assessment of myelin integrity in peripheral nerve injuries and pathologies has largely been
limited to post-mortem analysis owing to the difficulty in obtaining biopsies without affecting …

In this work a new MRI modality entitled Relaxation Along a Fictitious Field in the rotating
frame of rank 4 (RAFF4) was evaluated in its ability to detect lower myelin content in …

Purpose Models based on a sum of damped exponentials occur in many applications,
particularly in multicomponent T2 relaxometry. The problem of estimating the relaxation …

Specific magnetic resonance imaging (MRI) markers of myelin are critical for the evaluation
and development of regenerative therapies for demyelinating diseases. Several MRI …

Traumatic brain injury (TBI) is associated with various neurocognitive deficits, and rapid
assessment of the damage is potentially important for the prevention and treatment of these …

A novel lesion-mask free method based on a gamma mixture model was applied to myelin
water fraction (MWF) maps to estimate the association between cortical thickness and …