Importance Combining antidepressants is frequently done in the treatment of acute
depression, but studies have yielded conflicting results. Objective To conduct a systematic …

Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …

Most of the prescribing and dispensing of medicines happens in primary care.
Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation …

Introduction Ketamine intravenous therapy (KIT) appears effective for treating depression in
controlled trials testing a short series of infusions. A rapidly proliferating number of clinics …

Objective Despite the clinical importance of chronic and severe irritability, there is a paucity
of controlled trials for its pharmacological treatment. Here, we examine the effects of adding …

Introduction: Selective serotonin and norepinephrine reuptake inhibitors (SNRI) are among
the most prescribed antidepressants, and dose escalation is a frequently applied strategy …

Objective: Although repetitive transcranial magnetic stimulation (rTMS) is an effective
treatment for depression, little is known about the comparative effectiveness of rTMS and …

Objective: To evaluate the efficacy and tolerability of dose increase compared to dose
continuation of the initially prescribed antidepressant in antidepressant treatment failure …

Purpose Antidepressant consumption has risen in recent years, driven by longer treatment
duration. The objective of this study was to measure the prevalence of antidepressant long …